Drug-drug interactions: The importance of medication reconciliation

Objective:The main objective of this study aimed to assess drug–drug interactions (DDIs) in the cardiac care unit (CCU) and cardiac surgery units and the role of a clinical pharmacist in detecting and preventing the expected DDIs.Methods:This cross-sectional study was conducted in the CCU Units of Nemazee and Shahid Faghihi Hospitals, two referral hospitals in Shiraz, South of Iran, from August to February 2016. Patients older than 18 years, who were admitted and had received >24 h of inpatient services in these wards with two or more medication orders, were included in this study. All medication orders were evaluated by a pharmacist and DDIs were examined based on the Lexi-Interact™ software. In cases with serious DDIs (D or X), the physicians and nurses were informed, and intervention was conducted by a clinical pharmacist.Findings:A total of 3706 medical orders were evaluated. 6478 DDIs were detected, of which, 446 (6.88%) belonged to Classes D and X, and a total of 43.43% of all hospitalizations had at least one DDI. Factors with the most considerable influence on DDIs included an increased number of prescribed medications and patients underlying disease. The physicians accepted 62% of the interventions. The most frequent drugs responsible for interactions of Classes C, D, and X were aspirin, warfarin, and clopidogrel, respectively.Conclusion:This study shows that a significant number of clinical DDIs exist in hospitalized patients, especially among consumers of warfarin and aspirin. The role of a clinical pharmacist in preventing such interactions and safer pharmacotherapy management for hospitalized patients is essential.

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“…All DDIs were classified into five groups based on their clinical significance (A, B, C, D, and X). [6]…”

Section: Methodsmentioning

confidence: 99%

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

et al. 2019

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“…46% of medication error and 20% of adverse drug reactions occur in the hospital setting due to the lack of medication reconciliation [40]. Therefore medication reconciliation should be considered to reduce medication error as well as many efforts should be performed to foster all healthcare professionals to implement a medication reconciliation process [41].…”

Section: Strategies For Reducing and Preventing The Risk Of Drug Intementioning

confidence: 99%

Does Drug-drug Interactions Attain Enough Attention from Health Care Providers?

Nm¹

2018

Pharm Anal Acta

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Every year many patients are affected by adverse drug events that result from the complication of drug therapy. Drug-Drug Interactions (DDIs) are an expected subtype of adverse drug events. Most potential DDIs are preventable, but it remains a significant problem to patients and the health care system. Among the risk factors associated to DDIs include older age, comorbidities, polypharmacy and hospital stay for long time. DDIs are a considerable clinical problem in the hospitalized cardiac patients, cancer patients, hypertensive patients, and patients with immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Best management of DDIs involves the assessment of the interaction; decision to prescribe, dispense, or manage the interacting combination; follow-up monitoring and suitable patient counseling. Different studies were performed to detect and avoid DDIs. Different strategies have been introduced to reduce and prevent the risk of DDIs through the improvement of labeling on metabolic profile for new drugs and serious drug-drug and drug -gene combination, determination the effect of new guideline on product labeling changes for elderly patient and patients with polypharmacy. In clinical practice pharmacist can use good information sources; clinicians can use screening software for the detection and management of DDIs; consumers and patients can use decision support systems for potential DDIs and medication reconciliation should be considered by healthcare professionals to reduce medication error.

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“…Recognizing the drugs used regularly by the patient is a factor that will directly affect the selection of the drugs to be used in the treatment process. Many studies have showed that treatment success has increased signi cantly, thanks to patient-focused drug combinations (Makiani et al, 2017;W. Sun et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Identifying Side Effects of Some Drugs Used in Covid-19 Treatment

Aygün

Kaya

Alhajj

2020

Preprint

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To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. Organ systems and diseases in which these 8 drugs cause the most negative effects have been identified. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.

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Drug-drug interactions: The importance of medication reconciliation

Cited by 13 publications

References 2 publications

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

Does Drug-drug Interactions Attain Enough Attention from Health Care Providers?

Identifying Side Effects of Some Drugs Used in Covid-19 Treatment

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