Drug-drug interactions in the risky population: elderly, urological patients admitted to the intensive care unit

Bugday, Muhammet Serdar; Oksuz, Ersoy

doi:10.5505/ejm.2021.04864

Cited by 3 publications

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“…18 Other physiological alterations in the body increase the likelihood of developing DDIs in the elderly. 19 In light of this, the current study was conducted to evaluate the DDIs. Ceftriaxone, heparin, furosemide, warfarin, omeprazole, atorvastatin, and cimetidine in combination with each other or with other medicines were the most commonly noticed DDIs.…”

Section: Discussionmentioning

confidence: 99%

Drug–drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia’s Comprehensive Specialized Hospitals: A multicenter observational study

et al. 2022

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Objective: Drug–drug interactions are of major concern due to links to untoward drug effects, hospitalizations, and serious health impacts. Elderly patients are more predisposed to drug interactions than younger patients. The present study aimed to find out the prevalence of drug–drug interactions at North West Ethiopian compressive specialized hospitals’ Internal Medicine wards. Methods: From 30 April to 30 July 2021 GC, a multicenter prospective observational study was conducted at north Ethiopian specialized hospitals. Data was collected by using a structured questionnaire adapted from different literature and medical records at the North West Ethiopian Comprehensive Specialized Hospitals’ Internal Medicine wards during the study period. Thereafter checked the completeness of the collected data was checked drug–drug interactions by using Medscape. Epi data version 4.6.2 software was used as data clearance and STATA version 14.1 was used for further data analysis. Result: A total of 389 subjects participated in the study of which more than half (55.53%) of them were female with a mean (SD) age of 68.9 ± 7.46 years. A total of 641 drug–drug interactions were detected in this investigation of which, 225(35.1%) were major, 299(46.6%) were significant interactions, and 117(18.3%) were minor interactions. Hospital stay (AOR = 5.95 CI: 3.49–10.12), retire (AOR = 6.71 CI: 1.26–35.78), 5–9 drugs (AOR = 5.30 CI: 2.91–9.67) and more than 10 drugs (AOR = 8.03 CI: 2.47–26.07) were important risk factors for drug–drug interactions. Conclusion: The findings of this study suggest that drug–drug interactions were high among hospitalized elderly patients. The presence of polypharmacy, to be retired, and hospital stayed were all found to be strongly linked with drug–drug interactions.

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Section: Discussionmentioning

confidence: 99%

Drug–drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia’s Comprehensive Specialized Hospitals: A multicenter observational study

et al. 2022

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A meta‐analysis assessing the prevalence of drug–drug interactions among hospitalized patients

Aksoy,

Ozturk

2023

Pharmacoepidemiology and Drug

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PurposeDrug–drug interactions (DDIs), particularly in hospitalized patients can result in adverse drug events and unfavorable health consequences. The aim of this meta‐analysis is to provide up‐to‐date evidence on the prevalence of clinically evident adverse drug events due to DDIs in hospitalized patients.MethodsData from Scopus, PubMed, Cochrane and Web of Science were extracted using these keywords (Drug interaction/drug–drug interactions, Hospital/ hospitals, Adverse drug event, Hospitalized patients, inpatient, Department, Hospital stay, Harm, Mortality, death). The studies that include Observational studies on hospitalized patients, reporting potential DDIs using an electronic database, and reporting the clinically observed adverse drug interactions (ADI) through symptoms, signs or Laboratory tests are included. Using Open meta‐Software (version 12.11.14), the incidence of clinically evident DDIs among hospitalized patients was determined and shown in a forest plot.ResultsOnly 15 of the 8261 articles found through a literature search met the inclusion criteria and reported the desired outcome. The pooled prevalence of potential drug–drug interactions is 64.9% (CI 95% 0.618–0.736). While clinically evident DDIs have a pooled frequency of 17.17% (CI 95% 0.133–0.256).ConclusionThe issue of DDIs remains a significant concern in hospitalized patients, with a notable rise in their prevalence. This meta‐analysis encompassed a greater quantity of studies and demonstrated a heightened proportion of drug–drug interaction prevalence in comparison to the percentages reported in the previously published meta‐analysis.

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Drug-Drug Interactions in Hospitalized Urological Patients: A Retrospective Cohort Study

Milovanovic,

Pejcic

2024

Pharmacology

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Introduction: Exposure to potential drug-drug interactions (pDDIs) can be a notable source of avoidable drug-related harm that requires adequate management to prevent medical errors. We aimed to evaluate pDDIs and associated factors in hospitalized urological patients on admission, during hospitalization, and on discharge. Methods: A retrospective cohort study was conducted at the Clinic of Urology of the University Clinical Centre Kragujevac, Serbia. To detect pDDIs we used Lexicomp, which categorizes pDDIs as follows: X (Avoid combination), D (Consider therapy modification), C (Monitor therapy), B (No action needed) and A (No known interaction). Multiple linear regression analysis was used to identify factors associated with the number of pDDIs. Results: More than half of the 220 included patients had at least one pDDI on admission and discharge (57.3% and 63.6%, respectively), whereas 95.0% had at least one pDDI during hospitalization. The total number and number of X, D, C, and B categories of pDDIs were the highest during hospitalization and the lowest on admission. Duration of hospitalization, arrhythmias, dementia, renal failure, cancer, surgery during hospitalization, number of prescribed drugs, and various pharmacological drug classes were risk factors for a higher number of pDDIs, while age, ischemic heart disease, hypertension, and development of infection during hospitalization were protective factors in at least one of the stages. The impact of renal colic depended on the stage and category of pDDI. Conclusion: More than half of the urological patients were exposed to at least one pDDIs at all stages. Medical professionals should regularly screen for pDDIs, particularly in patients with risk factors.

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Drug-drug interactions in the risky population: elderly, urological patients admitted to the intensive care unit

Cited by 3 publications

References 0 publications

Drug–drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia’s Comprehensive Specialized Hospitals: A multicenter observational study

Drug–drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia’s Comprehensive Specialized Hospitals: A multicenter observational study

A meta‐analysis assessing the prevalence of drug–drug interactions among hospitalized patients

Drug-Drug Interactions in Hospitalized Urological Patients: A Retrospective Cohort Study

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