Drug-drug interactions in intensive care units and potential clinical consequences of these interactions

Oksuz, Ersoy; Bugday, Muhammet Serdar; Soyalp, Celaleddin; Karaaslan, Erol; Oto, Gökhan; Goceroglu, Rezzan Temelli; Berber, İlhami

doi:10.5455/annalsmedres.2019.07.430

Cited by 2 publications

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“…In another study, it was reported that potential drug-drug interactions (PDDI) occurred in 101 patients out of 111 patients treated in the ICU, and the number of deaths in these patients was 66.7% (Aşcı et al, 2016). In a study examining the most common potential clinical outcomes of DDIs in the ICU, it was determined that it caused an increased risk of bleeding (12.3%), hyperkalemia (8.2%), arrhythmia (7.9%), and CNS depression (6.6%) (Oksuz et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Practices of Nurses Working in Intensive Care on Drug-Drug Interaction

CAN

Yayan

2022

JSRMBS

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Purpose:This study was conducted to examine the knowledge and practices of nurses working in the intensive care unit about drug-drug interaction. Materials and Methods: This study was conducted with 186 intensive care nurses working in shifts in 12 intensive care units. "Nurse information form", "Drug-drug interaction questionnaire" prepared by the researcher, and "nurse observation form" were used in data collection. The data obtained from the study were evaluated in computer environment using frequency, percentage distribution and Chi-square test. Results:In the study, 76.3% of the nurses working in the intensive care unit reported that they did not know which of the drug pairs they encountered frequently caused drug-drug interactions. When the drugs administered by the nurses were examined, it was determined that 34.4% of them had the potential for drug-drug interaction. It was found that nurses' potential drug-drug interaction practices, staff status and working styles, and working time in the institution, profession and intensive care unit were not effective. It was determined that there were significant differences between the intensive care units (p=0.043) in the drug-drug interaction practices encountered. Conclusion:It was determined that the nurses did not have the desired level of knowledge about drug-drug interactions and interacting drug pairs, and there were differences between the intensive care units where they worked. It is recommended to increase the level of knowledge by giving regular trainings to nurses on drug-drug interaction.

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Section: Introductionmentioning

confidence: 99%

Knowledge and Practices of Nurses Working in Intensive Care on Drug-Drug Interaction

CAN

Yayan

2022

JSRMBS

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Determination of Potential Drug-Drug Interactions in Patients Using Quinolone Group Antibiotics

Ceylan,

Erden,

Göncüoğlu

et al. 2024

Genel Tıp Dergisi

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Aim: The aim of the study was to determine the potential drug drug interactions of patients receiving inpatient treatment in the intensive care unit and infectious diseases ward and using quinolone group antibiotics by using different interaction software programs. Material and Methods: The prescriptions of 100 patients who received inpatient treatment in infectious diseases service and intensive care unit at Selçuk University Faculty of Medicine Hospital between January 2022 and December 2022 and who were treated with quinolone group antibiotics during treatment were analyzed retrospectively. Results: Of the patients included in the study, 62 were male and 38 were female. The mean age of men was 65.76 ± 16.22 years, while the mean age of women was 68.63 ± 16.29 years. While Medscape® detected a total of 1776 interactions, this number was 1432 in Lexicomp® and 1693 in Drugs®.While 0.33% of the interactions detected in the Medscape® software program were contraindicated, 3.77% of the interactions were contraindicated in Lexicomp®. Kendall W coefficient 0.94, Chi-Square test 281.12, p <0.001 were found to be statistically significant. The software programs used to detect pDDIs are highly compatible with each other. Conclusion: High agreement was found between software programs used to detect potential drug-drug interactions. Interaction classifications between software programs are different. Therefore, clinicians may benefit from different software programs.

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Drug-drug interactions in intensive care units and potential clinical consequences of these interactions

Cited by 2 publications

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Knowledge and Practices of Nurses Working in Intensive Care on Drug-Drug Interaction

Knowledge and Practices of Nurses Working in Intensive Care on Drug-Drug Interaction

Determination of Potential Drug-Drug Interactions in Patients Using Quinolone Group Antibiotics

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