Drug-Drug Interaction Studies of Levocetirizine with Atenolol

Abstract

Abstract:The objective of the study was to evaluate the drug-drug interaction studies of levoceterizine with atenolol. Calibration curve studies of working standard solutions of levocetirizine and atenolol (0.01~0.1 mmol) were scanned. Maxima appeared at 231 nm for levocetirizine and 224 nm for atenolol. The calibration curve obeyed Beer Lambert's Law. Lone availabilities of both the drugs were studied in pH 1, pH 4, pH 7.4 and pH 9 at 37 °C on B.P. (British Pharmacopoeia) dissolution apparatus. To study the drug-drug interaction of levocetirizine (5 mg tablet) and atenolol (100 mg tablet), both the drugs were introduced to the dissolution apparatus in simulated gastric juice (pH 1), pH 4, pH 7.4 and pH 9 at 37 °C at zero time and measured the absorbance maxima of both the drugs at the corresponding wavelength. Graphs were plotted for availability percentage (%) of drug versus time at each set of experiment. The availability percentage (%) of levocetirizine in the buffers of pH simulated to gastric pH 4, pH 7.4 and pH 9 in the presence of atenolol was 436.78%, 376.90%, 436.78% and 436.78%, respectively, but the availability of atenolol was increased up to 214.80%, 212.96%, 214.93% and 231.51% in simulated to gastric pH and in the buffers of pH 4, pH 7.4 and pH 9, respectively. On the basis of these studies, it is concluded that levocetirizine forms a charge-complex with atenolol; therefore, co-administration of these drugs should be avoided.

Unraveling the Solvation Behavior of Levocetirizine Dihydrochloride: Insights from Volumetric, Acoustic, Viscometric, and Electronic Absorption Studies in Aqueous l-Proline and l-Valine Solutions

“…Although Liu and co-workersexplored the physical interactions between human serum albumin and LCTZ and Dena et alstudied the ion-pair formation between LCTZ and bromocresol green, the investigation solely relied on molecular spectroscopic and theoretical simulations, with the lack of a rigorous experimental analysis. Nevertheless, there are numerous studies investigating the pharmacodynamics and in vitro drug interaction studies of LCTZ, − yet surprisingly, there is a scarcity of research on the thermophysical behavior of such a prominent antihistamine/anti-inflammatory/antiallergic drug LCTZ in aqueous amino acid solutions. Recently, Zolkiflee and co-workers endeavored to elucidate interactions between l -cetirizine dihydrochloride and l -alanine/ l -glutamine.…”