Abstract:Aim: To evaluate drug–drug interaction (DDI) between tacrolimus (TAC)
and different formulations of voriconazole (VRCZ) in adults and
pediatrics with different ages. Method: Physiologically based
pharmacokinetics (PBPK) models were used to evaluate DDI between oral
TAC and different formulations of VRCZ (oral and intravenous (IV)
formulations) in adults and pediatrics with different age groups. Both
single dose and multiple dose administration were assessed. Multiple
dosage regimens were maintained for 7 days.… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.