Drug - Drug Interaction: An Important Drug Related Problem

Abstract

Drug interaction is defined as the clinical or pharmacological response occurs when two drugs administered simultaneously, results in beneficial or harmful effects in a person. Based upon mechanism of action drug interactions are classified in to three typ interactions, and Pharmaceutical interactions. Based upon severity, drug interactions are classified in to four types: Minor, moderate, major and contraindicated. According to WHO drug interactions are main cause of mortality and morbidity. It has been estimated that prevalence of interactions is estimated to be 1 22% in world. Drug-drug interactions accounted for 1.1% hospital admissions and 0.1% hospital visits.Polypharmacy, Age, Prescribing errors, some drug-drug interactions. These interactions lead to misinterpretation, alteration of affinity and efficacy of drugs, increased hospital cost, stay and admission, i incidence of adverse events and adverse drug reactions. Clinical pharmacist assisted computerised decision support systems will reduce alert fatigue by pharmacist decision on drug related problems. As these drug interactions effects the safety of patient health care professions should focus on these in clinical settings. echnology, Sri Padmavathi Mahila Viswavidyalayam, Tirupati, Andhra Pradesh Drug interaction is defined as the clinical or pharmacological response occurs when two drugs administered simultaneously, results in beneficial or harmful effects in a person. Based upon mechanism of action drug interactions are classified in to three types: Pharmacokinetic interactions, Pharmacodynamic interactions, and Pharmaceutical interactions. Based upon severity, drug interactions are classified in to four types: Minor, moderate, major and contraindicated. According to WHO drug interactions are main cause of mortality and morbidity. It has been estimated that prevalence of interactions is estimated to be 1 drug interactions accounted for 1.1% hospital admissions and 0.1% hospital visits. Polypharmacy, Age, Prescribing errors, some departments and some disease conditions are the reasons for drug interactions. These interactions lead to misinterpretation, alteration of affinity and efficacy of ital cost, stay and admission, increased morbidity and mortality incidence of adverse events and adverse drug reactions. Clinical pharmacist assisted computerised decision support systems will reduce alert fatigue by pharmacist decision on drug -drug interactions to avoid drug rug interactions effects the safety of patient health care professions should focus on these in clinical settings. interactions, Morbidity, Mortality, Adverse effects, Polypharmacy Drug interaction is defined as the clinical or pharmacological response occurs when two drugs administered simultaneously, results in beneficial or harmful effects in a person. Based upon mechanism of es: Pharmacokinetic interactions, Pharmacodynamic interactions, and Pharmaceutical interactions. Based upon severity, drug interactions are classified in to four types: Minor, moderate, major and contraindicated. Acc...