Drug-disease interactions: narrative review of aspirin in gastric ulcer

Nwose, Ezekiel Uba; Yee, KC

doi:10.1080/17425255.2016.1201064

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…This pathology is characterized by rupture of mucosal integrity in consequence of an imbalance between aggressive factors [acid gastric secretion, pepsin activity, and reactive oxygen species (ROS)] and the endogenous protective elements (mucus barrier, bicarbonate secretion, and adequate blood flow) of the gastric mucosa [ 4 ]. In addition, the occurrence of the gastric ulcer may be related to exogenous factors such as inadequate diet [ 5 ], alcohol consumption [ 6 ], prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) [ 7 ], and Helicobacter pylori infection [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

Nesello

Beleza

Mariot

et al. 2017

Gastroenterology Research and Practice

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This study evaluated the gastroprotective value of the methanol extracts from fruits of Morus nigra L. (black mulberry (MEMN)) and Rubus niveus Thunb (raspberry (MERN)). The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger activity. The gastroprotective effects of the extracts against 60% ethanol/0.3 M HCl were evaluated in mice. After that, the lipid hydroperoxides and reduced glutathione levels at ulcerated tissue were determined. The effects of extracts on H+/K+-ATPase activity were also verified. The extracts exhibited high contents of polyphenols; however, MERN presented 1.5-fold higher levels. The presence of flavonoids also was confirmed. In addition, MEMN (IC50 = 13.74 μg/mL) and MERN (IC50 = 14.97 μg/mL) scavenged DPPH radical. The MEMN reduced the ulcer area only at 300 mg/kg (p.o.) by 64.06%. Interestingly, MERN decreased the ulcer area in a superior potency (ED50 = 20.88 mg/kg), reducing the ulcer area by 81.86% at 300 mg/kg, and increased the gastric mucin levels. The antioxidant effects of extracts were evidenced by reduced lipoperoxides and increased reduction of glutathione amount in the gastric mucosa. However, MEMN or MERN did not change the H+/K+-ATPase activity. These results confirm that M. nigra and R. niveus are berries with a gastroprotective value by strengthening of gastric protective factors.

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Section: Introductionmentioning

confidence: 99%

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

Nesello

Beleza

Mariot

et al. 2017

Gastroenterology Research and Practice

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“…[18][19][20] Thus, conventionally, the administration of anticoagulant/antithrombotic drugs is contraindicated and discontinued in patients with gastrointestinal risks or events. 21 Studies have found that short-term interruptions in the administration of anticoagulant/ antithrombotic drugs can increase the incidence of thromboembolic and mortality-related events (see rebound-hypercoagulability. [22][23][24] Few individual retrospective cohort studies have attempted to compare the effects of continuation and discontinuation of anticoagulant/antithrombotic drugs due to gastrointestinal bleeding events.…”

Section: Introductionmentioning

confidence: 99%

The effects of anticoagulant therapy re‐initiation after gastrointestinal bleeding: A systematic review and meta‐analysis

Jingnan

Bao

et al. 2021

J Clin Pharm Ther

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What is known and Objective: Long-term anticoagulant/antithrombotic therapy is widely used for the management of thromboembolic conditions. Gastrointestinal bleeding is a common collateral manifestation of anticoagulant/antithrombotic therapy that complicates its administration. The continuation or discontinuation of anticoagulant/antithrombotic therapy after an episode of gastrointestinal bleeding has been a matter of debate. Despite recent positive reports from retrospective cohort studies suggesting a reduction in morbidity-and mortality-related outcomes with continued administration of anticoagulant/antithrombotic agents (even after gastrointestinal bleeding), no consensus or comparisons about the efficacies of continued or discontinued antithrombotic administration exist. Therefore, we developed this current state-of-evidence analysis evaluating the comparative effects of continuation and discontinuation of anticoagulant/antithrombotic drugs after gastrointestinal bleeding on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. Methods:We performed a systematic academic literature search according to the PRISMA guidelines across five databases: Web of Science, Embase, CENTRAL, Scopus and MEDLINE. Moreover, we conducted a random effect meta-analysis to compare the effects of continuation and discontinuation of anticoagulant/antithrombotic drugs after an event of gastrointestinal bleeding on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. Results:We found seven eligible studies (from 1397 candidates) with 2532 participants (mean age, 73.1 ± 4.1 years). Our meta-analysis revealed lower odds of thromboembolic events (OR, −0.21), mortality outcomes (OR, −0.39) and an increase in the incidence of gastrointestinal bleeding (OR, 2.4) in the group with continued anticoagulant/antithrombotic therapy than in the group discontinuing the therapy. What is new and Conclusion:We provide an updated evidence on the comparative effects between continuation and discontinuation of anticoagulant/antithrombotic drugs after gastrointestinal bleeding events based on the overall incidences of gastrointestinal bleeding, thromboembolic events and mortality events. This study reports confirm an overall lower incidence of thromboembolic events and mortality outcomes for the continuation group than for the discontinuation group.

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Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers (Tagetes erecta L.)

MEURER,

FELISBINO,

MÜLLER

et al. 2023

An. Acad. Bras. Ciênc.

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Drug-disease interactions: narrative review of aspirin in gastric ulcer

Cited by 3 publications

References 37 publications

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

The effects of anticoagulant therapy re‐initiation after gastrointestinal bleeding: A systematic review and meta‐analysis

Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers (Tagetes erecta L.)

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