2014
DOI: 10.1016/j.bmc.2014.02.036
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Drug discovery targeting cell division proteins, microtubules and FtsZ

Abstract: Eukaryotic cell division or cytokinesis has been a major target for anticancer drug discovery. After the huge success of paclitaxel and docetaxel, microtubule-stabilizing agents (MSAs) appear to have gained a premier status in the discovery of next-generation anticancer agents. However, the drug resistance caused by MDR, point mutations, and overexpression of tubulin subtypes, etc., is a serious issue associated with these agents. Accordingly, the discovery and development of new-generation MSAs that can obvia… Show more

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Cited by 66 publications
(41 citation statements)
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References 160 publications
(198 reference statements)
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“…The drug resistance has also led the path for targeting the prokaryotic cell division proteins as antimicrobials. Some studies show that FtsZ can be the best target in drug-resistant organisms [56]. Here, we have identified cell division protein FtsA as the target protein which anchors the FtsZ ring complex.…”
Section: Cell Cyclementioning
confidence: 96%
“…The drug resistance has also led the path for targeting the prokaryotic cell division proteins as antimicrobials. Some studies show that FtsZ can be the best target in drug-resistant organisms [56]. Here, we have identified cell division protein FtsA as the target protein which anchors the FtsZ ring complex.…”
Section: Cell Cyclementioning
confidence: 96%
“…The present protocol offered the opportunity to explore structural diversity by variation of the diazide structures and leaves room for further exploration of (10,12), tetra(triazole) macrocycles (11,13).…”
Section: Discussionmentioning
confidence: 99%
“…[11] As a member of the diterpenoids family, furanolabdanoid lambertianic acid 1 could be considered an ideal scaffold for receptors, due to its low toxicity and biocompatibility. [12,13] In recent years the copper(I)-catalyzed azide alkyne cycloaddition (CuAAC), the most frequently used "click" reaction, have emerged as efficient methodologies for the construction of a range of different macrocyclic structures for different purposes.…”
Section: Synthesis Of Novel Labdanoid-based Macroheterocyclesmentioning
confidence: 99%
“…Among the most intensively studied targets for the identification of novel antibacterial structure is the bacterial cytoskeleton (Celler et al 2013;Pilhofer and Jensen 2013;Ojima et al 2014). The dramatic increase in the understanding of the bacterial cytoskeleton as a control mechanism for coordinating bacterial cell growth has identified new antibacterial opportunity Pinho et al 2013;Wilson and Gitai 2013).…”
Section: New Synthetics As Antibacterialsmentioning
confidence: 99%