Drug Discovery from Plants

Salim, Angela A.; Chin, Young‐Won; Kinghorn, A. D.

doi:10.1007/978-3-540-74603-4_1

Cited by 82 publications

(103 citation statements)

References 93 publications

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“…1 The enormous variety of phytochemicals present in plants has positioned them as an invaluable source of medicines for humans, even after the latest advances in synthetic drug development. 2 Moreover, their beneficial effects seem to be improved in combinations of herbal remedies due to synergistic effects between different plants. In order to avail this kind of interaction, there are several studies supporting the optimization of plant-based products' application and aiming to explain the mechanisms underlying the synergistic actions between bioactive compounds of different herbs.…”

Section: Introductionmentioning

confidence: 99%

Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

et al. 2015

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aDue to the enormous variety of phytochemicals present in plants, their extracts have been used for centuries in the treatment of innumerable diseases, being perceived as an invaluable source of medicines for humans. Furthermore, the combination of different plants was reported as inducing an improved effect (synergism) in comparison with the additive activity of the plants present in those mixtures. Nevertheless, information regarding the effects of plant infusions added with honey is still rather scarce. Accordingly, the aim of this study was to evaluate the interaction between chestnut honey, a natural product with wellreported beneficial properties, and three medicinal plants (either as a single plant or as combinations of two and three plants), with regard to their antioxidant activity and hepatotoxicity. Antioxidant activity was evaluated by comparing the results from four different assays; hepatotoxicity was assessed in two different cell lines. Results were compared by analysis of variance and linear discriminant analysis. The addition of honey to the infusions had a beneficial result in both cases, producing a synergistic effect in all samples, except β-carotene bleaching inhibition for artichoke + milk thistle + honey preparation and also preparations with lower hepatotoxicity, except in the case of artichoke + honey. Moreover, from the discriminant linear analysis output, it became obvious that the effect of honey addition overcame that resulting from using single plant or mixed plant based infusions. Also, the enhanced antioxidant activity of infusions containing honey was confirmed by lower hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

et al. 2015

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“…Apart from this, other investigations also revealed that methanol extracts of individual plants were more effective than their respective aqueous extracts (Opoku et al, 2000;Shoba and Thomas, 2001). This might be due to the possible presence of organic compounds, particularly the phytochemicals which were reported to be indirect contributors of plant growth and development, in methanol extract (Murphy et al, 2000;Salim et al, 2008). However, it might also be explained in the opposite way, whereby, the non-polar compounds present abundantly in methanol extracts might not have thoroughly dissolved in water; hence, expressed the effect of tap water rather than that of the extract itself.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

Rathnasamy¹,

Mohamed²,

Sulaiman³

et al. 2013

Int Curr Pharm J

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In the present study, the Allium cepa chromosome assay was employed as a preliminary test to investigate the mutagenic and antimutagenic potential of three plants, namely Clinacanthus nutans, Adhatoda vasica, and Carica papaya, used by traditional practitioners in Malaysia against a direct acting mutagen-Methyl Methanesulphonate (MMS). Onions were planted in various treatment groups: plant extract alone, treatment 1 (pre-treatment with MMS and transfer into plant extracts), and treatment 2 (mixture of MMS and plant extracts). The bulbs planted in the extract alone for cytotoxicity and mutagenicity assessment revealed that none of the extracts of the three plants except the 50 mg/kg of methanol extract of A. vasicawere cytotoxic to A. cepa cells, but a moderate level of mutagenicity was observed at 200 and 400 mg/kg of methanol extract of C. papaya and at 400 mg/kg of aqueous extract of C. nutans. Antimutagenic screening on the other hand revealed that all the extracts tested were able to reduce the percentage chromosomal aberration induced by MMS, both in treatment 1 and 2. Besides that, MMS-induced cell death was also observed to be reduced in onion root cells treated with the plant extracts. Therefore, taking all the results obtained into consideration, the order of the plant extracts with increasing suppressiveness against MMS was C. papaya < A. vasica < C. nutans.DOI: http://dx.doi.org/10.3329/icpj.v2i8.15588 International Current Pharmaceutical Journal, July 2013, 2(8): 131-140

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“…According to World Health Organization, traditional herbal remedies are still extensively used, especially in rural regions with restricted access to modern medicines [3]. Investigation of pain relief potential of plant-based remedies used in traditional medicine is one viable way of discovering new analgesic agents which could be beneficial in pain management [4].…”

Section: Introductionmentioning

confidence: 99%

In vivo analgesic activities and safety assessment of Vitis vinifera L and Punica granatum L fruits extracts

Zeghad¹,

Aicha²,

Sihem³

et al. 2017

Trop. J. Pharm Res

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Drug Discovery from Plants

Cited by 82 publications

References 93 publications

Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

In vivo analgesic activities and safety assessment of Vitis vinifera L and Punica granatum L fruits extracts

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