Drug diffusion front movement is important in drug release control from swellable matrix tablets

Colombo, Paolo; Bettini, Ruggero; Massimo, Gina; Catellani, P. L.; Santi, Patrizia; Peppas, Nikolaos A.

doi:10.1002/jps.2600840816

Cited by 196 publications

(117 citation statements)

References 23 publications

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“…This property has been utilized in the formulation of dosage forms (Nakano and Ogata, 1984) where the powdered drug is embedded within the matrix of hydrophilic polymeric materials and compressed to produce matrix tablets. The release of drug from such hydrophilic matrices is described as a complex interaction between swelling, diffusion and erosion (Harland et al, 1988;Peppas and Sahlin, 1989;Colombo et al, 1990;Lee and Kim, 55 1991; Colombo et al, 1992;Colombo et al, 1995;Reynolds et al, 1998;Munday and Cox, 2000;Ghori et al, 2014a).…”

Section: Introductionmentioning

confidence: 99%

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep

Asare-Addo

Ghori

et al. 2015

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep

Asare-Addo

Ghori

et al. 2015

International Journal of Pharmaceutics

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“…Water soluble drugs as fenoterol HBr are mainly released by diffusion of dissolved drug molecules across the gel layer formed after polymer swelling, while poorly water soluble drugs are more likely released through the gel erosion. When the release mechanism involves the synchronization of swelling and erosion rates, the matrix may provide zero-order release kinetics (11,12).…”

Section: Polyox ® Wsr 303mentioning

confidence: 99%

Preparation and In-vivo Pharmacokinetic Study of a Novel Extended Release Compression Coated Tablets of Fenoterol Hydrobromide

Elshafeey

Sami

2008

AAPS PharmSciTech

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Abstract. The aim of this study was to formulate extended release compression coated core tablets of fenoterol hydrobromide, a selective β 2 adrenergic receptor agonist, in an attempt to prevent nocturnal asthma. Two hydrophilic polymers viz Kollidon ® SR, Polyox ® WSR 303 and a hydrophobic one (Precirol ® ATO5) were employed. Compression coated tablets were formulated by preparing a core tablet containing 7.5 mg drug and various amounts of polymer and Emcompress ® then compressed coated with the same polymeric materials. For comparison purpose different matrix tablets were also prepared employing the same polymers. In-vitro release studies were carried out at different pH (1.2 and 6.8). Pharmacokinetics of extended release tablets as well as commercially available immediate release tablets (Berotec ® ) were studied after oral administration to beagle dogs using a new developed LC-MS/ MS method with a lower limit of quantification of 1 ng/ml. Fenoterol release from compression coated tablets was significantly lower than matrix tablets. The mechanism of release was changed with the nature and content of polymer. The release pattern of drug from F16 containing 40 mg Kollidon ® SR divided in the core tablet (15 mg) and the rest in the compressed coat (25 mg) showed a typical zero order release kinetic that could extend drug release >10 h and reasonable time for 75% to be released (t 75 ) (8.92 h). When compared to immediate release Berotec ® tablet the MRT was significantly extended from 7.03±0.76 to 10.93±1.25 h (P<0.001) and HVD t 50%Cmax was also significantly extended from 2.71±0.68 to 6.81±0.67 h with expected prevention of nocturnal asthma.

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“…They hydrate and swell on contact with water forming the gel layer controlling drug release from the tablet matrices. Drug release from these matrices has been shown to be a complex interaction between swelling, diffusion and erosion (Harland et al, 1988;Peppas and Sahlin, 1989;Lee and Kim, 1991;Colombo et al, 1995;Reynolds et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sesamum gum as an excipient in matrix tablets

Nep

Asare-Addo²,

Ngwuluka

et al. 2016

British Journal of Pharmacy

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In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.

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Drug diffusion front movement is important in drug release control from swellable matrix tablets

Cited by 196 publications

References 23 publications

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Preparation and In-vivo Pharmacokinetic Study of a Novel Extended Release Compression Coated Tablets of Fenoterol Hydrobromide

Evaluation of sesamum gum as an excipient in matrix tablets

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