Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy

Wang, Chao; Cheng, Liang; Liu, Zhuang

doi:10.1016/j.biomaterials.2010.09.069

Cited by 614 publications

(400 citation statements)

References 36 publications

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“…[27][28][29][30] The cytotoxicity of NaGdF 4 -AFn-FA was therefore studied by using standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays with the MCF-7 cell line, and the results are shown in Figure 4A.M CF-7 cells were incubated with variousN aGdF 4 -AFn-FAc oncentrations, ranging from 6.25 to 200 mgmL…”

Section: Nagdf 4 -Afn-fac Ytotoxicity In Vitromentioning

confidence: 99%

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

et al. 2017

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To develop a multifunctional nanomaterial for dual‐mode imaging and synergetic chemotherapy, curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4 nanomaterial, then apoferritin (AFn) loaded with doxorubicin (DOX) was attached to the NaGdF4 surface. Subsequent modification with the targeting reagent folic acid (FA) led to generation of the CUR/NaGdF4–DOX/AFn–FA conjugate for cancer treatment. X‐ray diffraction, scanning (SEM) and transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy demonstrated the successful preparation of hexagonal‐phase NaGdF4 and NaGdF4–AFn–FA. Moreover, no toxicity was observed for NaGdF4–AFn–FA. In vitro and in vivo experiments demonstrated that the two drugs are sequentially released from the nanocomposites. This two‐drug system showed strong growth inhibitory effects on MCF‐7 cells. Upconversion luminescence imaging and magnetic resonance (MR) imaging of NaGdF4–AFn–FA were carried out. The results of this study show that NaGdF4–AFn–FA can be used for targeted anticancer drug delivery as well as imaging, a novel multi‐pronged theranostic system for tumor treatment.

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Section: Nagdf 4 -Afn-fac Ytotoxicity In Vitromentioning

confidence: 99%

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

et al. 2017

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“…Up to now, most of the UCNPs drug delivery system were realized by coating PEG or mesoporous silica for probe attachment or drug loading [89][90][91][92]. Liu and coworkers functionalized UCNPs with a PEG grafted amphiphilic polymer.…”

Section: Ucnps For Cancer Therapymentioning

confidence: 99%

“…Then the PEGylated UCNPs were loaded with DOX molecules and conjugated with FA for targeted drug delivery and cell imaging. The loading and releasing of DOX from UCNPs are controlled by varying pH, with an increased drug dissociation rate in acidic environment, favorable for controlled drug release [89]. Cui and coworkers reported a multifunctional "nanorattle" hollow spheres that consist of RE-doped NaYF 4 shells with a SiO 2 -coated Fe 3 O 4 inner particle.…”

Section: Ucnps For Cancer Therapymentioning

confidence: 99%

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Yang¹,

Han²,

Yue³

2016

Nano BioMed ENG

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As a new generation of fluorophores, up-conversion nanoparticles (UCNPs) exhibit high penetration depth in tissues, low photodamage to biological samples, large Stokes shifts, sharp emission bands, free auto-fluorescence background and high photostability, thus making them an ideal kind of fluorescent labels for a variety of assay formats ranging from bio-imaging to cancer therapy. In this article, the method for the synthesis of biocompatible UCNPs, the recent progress regarding the UCNPs for multimodal targeted tumor imaging, drug delivery, photodynamic therapy (PDT), and photothermal therapy (PTT) are discussed on emphasis. The challenges and opportunities in this emerging field are also presented.

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“…To overcome these limitations, many research groups found that upconversion nanoparticle (UCNP)‐based probes are promising and could be one of solutions. Compared with conventional fluorescence probes, UCNPs have many charming factors such as high chemical stability,14, 15 non‐autofluorescence from biosamples,16, 17, 18 large light penetration depth,19, 20, 21 long lifetime (millisecond scale),22, 23 and less damage to samples 24, 25, 26, 27, 28…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

2018

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Significant progress on upconversion‐nanoparticle (UCNP)‐based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non‐autofluorescence, high chemical stability, large light‐penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide‐doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP‐based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.

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Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy

Cited by 614 publications

References 36 publications

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

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Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy

Cited by 614 publications

References 36 publications

A Hollow NaGdF4/AFn Nanosystem Based on “Relay Race” Release for Therapy

A Hollow NaGdF4/AFn Nanosystem Based on “Relay Race” Release for Therapy

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

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A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy

A Hollow NaGdF₄/AFn Nanosystem Based on “Relay Race” Release for Therapy