Drug Delivery Using Nanoparticle‐Stabilized Nanocapsules

Yang, Xiaochao; Agasti, Sarit S.; Jeong, Youngdo; Zhu, Zheng‐Jiang; Rana, Subinoy; Miranda, Oscar R.; Rotello, Vincent M.

doi:10.1002/anie.201005662

Cited by 118 publications

(107 citation statements)

References 50 publications

(12 reference statements)

Supporting

Mentioning

107

Contrasting

Order By: Relevance

“…directly at the site of interest at high concentrations, while reducing systematic toxicity at healthy regions. [1][2][3] Advances in interfacial and surface chemistry have enabled development of advanced nanocarrier systems as versatile medical tools as their properties can easily be tuned for diagnostic and therapeutic applications. [4][5][6][7] Consequently extensive efforts have been focused require tedious synthesis and purifi cation protocol, special peptide sequences, [ 24 ] and toxic chemicals during its preparation and displayed low polydispersity index (PdI) < 0.1 necessary for effi cient drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

Jakhmola

Vecchione

Guarnieri

et al. 2015

Adv Healthcare Materials

View full text Add to dashboard Cite

The application of multimodal systems in the field of nanomedicine is advantageous as they can perform two or more tasks simultaneously. Here a robust approach is presented mimicking biogenic silica to design a multilayered nanocarrier system with a central oil core encapsulated within a polymer-silica shell. The outermost silica shell has been deposited through a biosilicification process induced by poly-L-lysine molecules immobilized on the surface of emulsion droplets. This system can be simultaneously loaded with high amount of hydrophobic molecules or contrasting agents in the inner oil core, while the polymeric-silica layers can be easily tagged with at least two different contrasting agents. Additionally, the zwitterionic nature of the silica precipitating peptide (poly-L-lysine) has been efficiently exploited to modulate and entirely reverse the surface charge of the nanocarrier without using any additional coating material. It has been demonstrated experimentally that the designed nanocapsular system is monodisperse, nontoxic, cargo protective, tunable in thickness, fluorescent, and magnetic resonance imaging (MRI) active so highly versatile for multiple applications in the field of drug delivery and in vivo imaging.

show abstract

Section: Introductionmentioning

confidence: 99%

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

Jakhmola

Vecchione

Guarnieri

et al. 2015

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Adsorption processes on interfaces are of great importance in a wide spectrum of scientific and industrial applications such as the stabilization of foams [1], the formulation of nanoporous materials, functional membranes and capsules, drug delivery [2,3] and oil recovery [4], to name but a few. Also, many aerated food products such as bread cake, meringue, ice-cream and mousse are based on stabilized emulsions.…”

Section: Introductionmentioning

confidence: 99%

General framework for adsorption processes on dynamic interfaces

Schmuck

Kalliadasis

2016

J. Phys. A: Math. Theor.

View full text Add to dashboard Cite

Abstract. We propose a novel and general variational framework modelling particle adsorption mechanisms on evolving immiscible fluid interfaces. A by-product of our thermodynamic approach is that we systematically obtain analytic adsorption isotherms for given equilibrium interfacial geometries. We validate computationally our mathematical methodology by demonstrating the fundamental properties of decreasing interfacial free energies by increasing interfacial particle densities and of decreasing surface pressure with increasing surface area.

show abstract

“…Nanoparticle-stabilized capsule (NPSC) is a new delivery platform that enables the direct cytosolic delivery of a large variety of therapeutics, including proteins, small-interfering RNAs and chemotherapy drugs [9]. Gold nanoparticles (AuNPs) were used in NPSCs as modular building blocks to incorporate particle properties to expand overall functionality.…”

mentioning

confidence: 99%

Nanoparticle–Dendrimer Hybrid Nanocapsules for Therapeutic Delivery

Jeong

Kim

Jiang

et al. 2016

Nanomedicine (Lond.)

Self Cite

View full text Add to dashboard Cite

Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamatefunctionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.

show abstract

Drug Delivery Using Nanoparticle‐Stabilized Nanocapsules

Cited by 118 publications

References 50 publications

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

General framework for adsorption processes on dynamic interfaces

Nanoparticle–Dendrimer Hybrid Nanocapsules for Therapeutic Delivery

Contact Info

Product

Resources

About