Drug delivery using alginate and chitosan beads: An Overview

Bhattarai, Rajan; Dhandapani, Nagasamy Venkatesh; Shrestha, Ayush

doi:10.4103/2229-5186.93023

Cited by 25 publications

(11 citation statements)

References 26 publications

(54 reference statements)

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“…Previous studies had proved that more effective beads for the compounds entrapment can be formed by using a combination of both alginate and another polymer such as pectin or chitosan (Bhattarai, Dhandapani, Shrestha, 2011;Jaiswal et al, 2009;Zam et al, 2013).…”

Section: Flaxseed Oil Encapsulation Efficiency (%)mentioning

confidence: 99%

Encapsulation of flaxseed oil extract in alginate-salep system by ionic gelation

Zam

Housheh

2019

Braz. J. Pharm. Sci.

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The objective of the current study was to encapsulate flaxseed oil extracted from finely grounded flaxseed powder and determined for its fatty acids content by GC/FID. Ionotropic gelation method was used to form beads containing 40% flaxseed oil with vitamin E being used as an antioxidant agent. The study employed calcium chloride solution as crosslinking agent with a combination of sodium alginate and salep. The effect of polymer concentrations and calcium chloride concentration on the morphology, entrapment efficiency and oil release was studied. The encapsulation efficiency reached 93.46 ± 0.064% using 0.6% of salep and 2% sodium alginate with 0.3M calcium chloride gelling solution. In SGF medium, the matrix released only about 28.56% of the entrapped flaxseed oil after 2 hours. The rest of the oil then released in the SIF medium, continuing for up to 5 h to release 99.32% of the oil.

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Section: Flaxseed Oil Encapsulation Efficiency (%)mentioning

confidence: 99%

Encapsulation of flaxseed oil extract in alginate-salep system by ionic gelation

Zam

Housheh

2019

Braz. J. Pharm. Sci.

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“…The drug content is expressed as the percentage of drug encapsulated in a unit weight of beads. The experiments are carried out in triplicate and the results were averaged [20][21][22][23][24].…”

Section: Fig 4: In Vitro Swelling Data Of Cefdinir Beads (Fb1-fb4)mentioning

confidence: 99%

Formulation and Characterization of Floating Beads of Antibiotic by Emulsion Gelation Technique

My¹,

N²

2019

Asian J Pharm Clin Res

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Objective: The study aims at formulation and characterization of floating hydrogel beads of cefdinir for improving its bioavailability. Methods: Cefdinir is broad-spectrum, oral, third-generation cephalosporin antimicrobial agent active against Gram-positive and Gram-negative bacteria. The floating hydrogel beads of cefdinir were formulated with polymers such as sodium alginate and sodium carboxymethyl cellulose by emulsion gelation technique using olive oil/castor oil. The beads were evaluated for surface morphology, bead size, entrapment efficiency, floating characteristics, in vitro swelling, in vitro drug release, and stability studies. Results: On the basis of evaluation, all the beads show good swelling up to 12 h in 0.1 N hydrochloric acid. The swelling was followed by values in order of vegetable oil > mineral oil in case of emulsion gelation method. Scanning electron microscopy study shows that beads were spherical in shape. Comparing all the formulations, formulation FB12 was considered as optimized formulation which shows % yield 94.06±0.11, % floating 87.28±0.90, in vitro drug release 94.68, and also stable in stability studies. Conclusion: From the findings, it may be concluded that cefdinir-loaded floating beads were successfully prepared and proved to be useful for the better bioavailability and patient compliance for enhanced antimicrobial activity.

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“…The drug content is expressed as the percentage of drug encapsulated in a unit weight of beads. The experiments are carried out in triplicate and the results averaged (Chaturvedi et al, 2012;Piyakulawat, 2007;Bhattarai, 2011).…”

Section: In-vitro Drug Release Studiesmentioning

confidence: 99%

Preparation and evaluation of gastroretentive hydrogel beads of Cefdinir by ionotropic gelation method

Khalifa¹,

Saleem²,

Siraj³

et al. 2019

Asian J Pharm Pharmacol

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Objective: The purpose of the present study was to develop and evaluate gastroretentive hydrogel beads of Cefdinir using polymers like Sodium alginate and Sodium CMC by ionotropic gelation method using Calcium carbonate or sodium bicarbonate as a gas forming agent. Twelve formulated beads evaluated physically in Materials and Methods: terms of floating characteristics, surface morphology, bead size, entrapment efficiency, Fourier transform infrared spectroscopy, in vitro swelling, and in drug release and stability studies. The surface morphology vitro Results: revealed that the prepared beads are spherical, having rough and dense surface with microscopic cracks and wrinkles on the surface. Formulations F5 shows higher According to nature of coagulation medium the shape of beads was changed. drug entrapment efficiency (i.e. 94.60%) suggesting that the ionotropic gelation method is effective for the entrapment of Cefdinir. All the beads formulation remained float throughout the study up to 24 h with the range of 62.25-96.40% suggesting that calcium carbonate and sodium bicarbonate can be used as buoyant. All the beads show good swelling up to 12 hrs in 0.1 N HCL. The swelling followed values in order of sodium carboxy methyl cellulose > sodium alginate. The in vitro drug release indicated that increase the concentration of gas forming agent increase the drug release and drug release followed values in order of sodium alginate > sodium CMC. Also increase in concentration of the polymer resulted in decreased drug release. It can be concluded that the floating beads of cefdinir can be prepared Conclusion: by using CaCO and NaHCO as buoyant along with hydrogel forming polymer like sodium alginate and sodium 3 3 carboxy methylcellulose as a release modifier for improved oral bioavailability of Cefdinir.

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Drug delivery using alginate and chitosan beads: An Overview

Cited by 25 publications

References 26 publications

Encapsulation of flaxseed oil extract in alginate-salep system by ionic gelation

Encapsulation of flaxseed oil extract in alginate-salep system by ionic gelation

Formulation and Characterization of Floating Beads of Antibiotic by Emulsion Gelation Technique

Preparation and evaluation of gastroretentive hydrogel beads of Cefdinir by ionotropic gelation method

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