Drug Delivery through Liposomes

Abstract

Several efforts have been focused on targeted drug delivery systems for delivering a drug to a particular region of the body for better control of systemic as well as local action. Liposomes have proven their efficiency as a choice of carrier for targeting the drugs to the site of action. The main reason for continuous research on liposomes drug delivery is they largely attributed to the fact that they can mimic biological cells. This also means that liposomes are highly biocompatible, making them an ideal candidate for a drug delivery system. The uses found for liposomes have been wide-spread and even include drug delivery systems for cosmetics. Several reports have shown the applicability of liposomal drug delivery systems for their safe and effective administration of different classes of drugs like anti tubercular, anti cancer, antifungal, antiviral, antimicrobial, antisense, lung therapeutics, skin care, vaccines and gene therapy. Liposomes are proven to be effective in active or passive targeting. Modification of the bilayer further found to increase the circulation time, improve elasticity, Trigger sensitive release such as pH, ultrasound, heat or light with appropriate lipid compositions. The present chapter focuses on the fundamental aspects of liposomes, their structural components, preparation, characterization and applications.

Nano‐biotechnology in tumour and cancerous disease: A perspective review

“…Liposomes can encapsulate hydrophilic substances in their aqueous core or integrate lipophilic and amphiphilic drugs into their phospholipid membrane. Therefore, liposome formulations can improve the safety and efficacy of drug delivery at the site of action 132 . Lipid‐based NPs, also known as LBNPs, are a particularly important type of nanoparticle for cancer therapy due to their breadth and diversity.…”

“…Therefore, liposome formulations can improve the safety and efficacy of drug delivery at the site of action. 132 Lipid-based NPs, also known as LBNPs, are a particularly important type of nanoparticle for cancer therapy due to their breadth and diversity. Liposomes are widely used not only because they come in a variety of shapes and sizes, but also because they are highly biocompatible and can contain a wide range of cargoes.…”

Development and Characterization of Soy Lecithin Liposome as Potential Drug Carrier Systems for Doxorubicin

“…When liposomes have charge means, repulsive forces increase and the medium becomes stable. Zeta potential lesser than −30 mV or greater than 30 mV is considered to be more stable [25]. So, the magnitude of the zeta potential increase from −26.9 to −22.3 mV gives a sign of the potential stability of the sample, by increasing the repulsion between particles.…”