Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design

Barua, Sonia; Kim, Hyeongmin; Jo, Kanghee; Seo, Chang Won; Park, Tae Jun; Lee, Kyung Bin; Yun, Gyiae; Oh, Kyungsoo; Lee, Jaehwi

doi:10.1007/s40005-016-0281-9

Cited by 32 publications

(19 citation statements)

References 154 publications

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“…The viscosity and mucoadhesion support rendered by saliva is attributed to the presence of glycoprotein mucin. The drug permeation via the buccal route takes place mainly by the paracellular and transcellular route (Barua et al, 2016;Boddupalli, Mohammad, Nath, & Banji, 2010). The sublingual area, currently the most widely utilized oral transmucosal site, is more vascular as compared to the buccal mucosa.…”

Section: Introductionmentioning

confidence: 99%

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

Kumar¹,

Bharti²,

Kumar³

2020

IJP

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Background and Aim: Buccal/sublingual drug delivery is gradually becoming one of the most experimented routes for alternate drug delivery. The major advantage of both routes is their high vascularity that allows a substantial permeation of drugs into systemic circulation. Mucoadhesive biopolymers are the mainstay of a transmucosal drug delivery system. Methods: We formulated blank tablets of explored mucoadhesive biopolymers (sodium alginate, carboxymethyl cellulose, hydroxyl propyl methyl) cellulose using a combination of two at a time. The novelty of this script lies in the formation of tablets using the FTIR hydraulic press, as opposed toa conventional tablet punching machine, at two different pressures. The tablets were subjected to basic characterizations of polymeric interaction, hardness, and swelling behaviour. Results: An interaction analysis using XRD revealed a good interaction between the polymers. HC-300 and AC-300 were found to be the hardest among the tablets formulated. In terms of swelling behaviour, AC-200 and HA-300 displayed the best swelling as compared to other combinations. Conclusion: In the absence of a conventional tablet punching machine, we fabricated swellable biopolymeric tablets using the regular KBr hydraulic press that comes as an accessory with the FTIR instrument. These tablets can possible be used for delivering drugs through buccal mucosa.

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Section: Introductionmentioning

confidence: 99%

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

Kumar¹,

Bharti²,

Kumar³

2020

IJP

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“…The latter is the gold standard for medicines and the most common process used for self-administered drug intake. Recently, buccal permeation (items i and ii) strategies increased in number of developments; this route bypasses hepatic and gastrointestinal effects, which is advantageous to sensitive drugs (Barua et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery

et al. 2019

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Oral route maintains its predominance among the ones used for drug delivery, especially when medicines are self-administered. If the dosage form is solid, therapy gains in dose precision and drug stability. Yet, some active pharmaceutical substances do not present the required solubility, permeability, or release profile for incorporation into traditional matrices. The combination of nanostructured drugs (nanoparticle [NP]) with these matrices is a new and little-explored alternative, which could bring several benefits. Therefore, this review focused on combined delivery systems based on nanostructures to administer drugs by the oral cavity, intended for buccal, sublingual, gastric, or intestinal absorption. We analyzed published NP-in-matrix systems and compared main formulation characteristics, pharmacokinetics, release profiles, and physicochemical stability improvements. The reported formulations are mainly semisolid or solid polymers, with polymeric or lipid NPs and one active pharmaceutical ingredient. Regarding drug specifics, most of them are poorly permeable or greatly metabolized. The few studies with pharmacokinetics showed increased drug bioavailability and, sometimes, a controlled release rate. From our knowledge, the gathered data make up the first focused review of these trendy systems, which we believe will help to gain scientific deepness and future advancements in the field.

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“…1.1.1 Introduction of Buccal Drug delivery system (1,2) Bioadhesive medication conveyance details were presented in 1947 when gum tragacanth was blended with dental glue powder to apply penicillin to the oral mucosa. As of late conveyance of remedial specialists by means of Mucoadhesive medication conveyance framework has turned out to be very fascinating.…”

Section: Introduction Of Drug Delivery Systemmentioning

confidence: 99%

“Formulation and Evaluation of Buccal Films of Saxagliptin”

Pandit

Patel

2019

IJPBA

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Objective: Saxagliptin is an orally anti-diabetic drug. It has an oral bioavailability of 50% due to first pass hepatic metabolism. To achieve sustained action of drug, reduce dosing frequency, bypass the hepatic first pass effect and improve bioavailability, buccal films formulation was planned. Methods: Compatibility of the drug with the excipients was studied with the help of FTIR. 23 factorial design was planned using concentration of Sodium alginate, concentration of Chitosan and PEG 400. Solvent casting method was used for the fabrication of films. Weight, thickness, surface pH, mucoadhesive strength, in vitro residence time, % swelling and % drug release were evaluated for the prepared film formulations. Results: All the films were found have surface pH close to neutral pH and were found to have content uniformity. Mucoadhesive strength was found to increase with increase in concentration of Chitosan. Drug release is more controlled by the high swelling film formers than sodium alginate. Among the film formers, though swelling is more, % drug release is also more from sodium alginate and Chitosan films because of its ionic nature and more solubility. Conclusion: Because of high mucoadhesive strength and more % drug release, combination of Sodium alginate with Chitosan film formulations was selected. Key Words: Saxagliptin, Buccal films

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Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design

Cited by 32 publications

References 154 publications

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery

“Formulation and Evaluation of Buccal Films of Saxagliptin”

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