Drug Delivery Systems for the Treatment of Diabetes Mellitus: State of the Art

Adams, Gary G.; Harding, Stephen E.

doi:10.2174/13816128113199990367

Cited by 9 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pulmonary route of insulin delivery appears to be a feasible option to enhance this synchronization as lungs with thin epithelium, rich blood supply and a vast absorbing surface help in rapid absorption of insulin delivered to it. [ 5 11 12 13 14 ]…”

Section: Introductionmentioning

confidence: 99%

Inhaled insulin: A “puff” than a “shot” before meals

Brashier

Khadka

Anantharamu

et al. 2015

Journal of Pharmacology and Pharmacotherapeutics

View full text Add to dashboard Cite

Diabetes is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. The main treatment of diabetes relies on subcutaneous insulin administration by injection or continuous infusion to control glucose levels, besides oral hypoglycemic agents for type 2 diabetes. Novel routes of insulin administration are an area of research in the diabetes field as insulin injection therapy is burdensome and painful for many patients. Inhalational insulin is a potential alternative to subcutaneous insulin in the management of diabetes. The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium facilitates systemic delivery of insulin via pulmonary administration. Inhaled insulin has been recently approved by Food and Drug Administration (FDA). It is a novel, rapid-acting inhaled insulin with a pharmacokinetic profile that is different from all other insulin products and comparatively safer than the previous failed inhaled insulin (Exubera).

show abstract

Section: Introductionmentioning

confidence: 99%

Inhaled insulin: A “puff” than a “shot” before meals

Brashier

Khadka

Anantharamu

et al. 2015

Journal of Pharmacology and Pharmacotherapeutics

View full text Add to dashboard Cite

show abstract

“…Thus, therapeutic proteins are commonly administered by parenteral route, with insulin, for instance, being administered subcutaneously in the treatment of diabetes mellitus. However, oral administration is regarded as a better, cost-effective and acceptable route of administration that circumvents the use of needles and other injection materials [42]. Therefore, several attempts have been made to develop oral carriers able to deliver insulin in a continuous and efficient manner, avoiding local pain, immune reactions and potential contamination.…”

Section: Core Tags In the Clustermentioning

confidence: 99%

Food biotechnology

Foster

Adams

Bari

et al. 2020

Current Opinion in Chemical Engineering

Self Cite

View full text Add to dashboard Cite

We investigate recent advances in the Chemical Engineering aspects of food structuring agents and macronutrients: carbohydrates, proteins and lipids, and also the fate of food upon ingestion. Prebiotic effects on host-microbe interactions enable improved immune response and pathogen control. Formulation Engineering is an emerging area in the field of Chemical Engineering and requires detailed knowledge of the materials used, and the processes by which they are transformed / functionalised into products. Understanding 'comb-like' polymers and their interactions provide new structuring opportunities. Sustainable sourcing of alternative protein sources, natural lipid organelles and structuring of liquid oils are framed in a waste valorisation approach, utilising biotechnological approaches for new functionalities. Controlling natural and fabricated microstructures enable controlled digestion profiles. Author Comments:Apologies -I have now annotated the selected priority references. I have also attached a CORRECTED FINAL version of the manuscript

show abstract

“…A drug delivery system (DDS) supplies a predetermined drug releasing profile which ensures an optimal absorption of the drug to improve its safety and efficacy. 3D microscale or nanoscale systems [50][51][52][53][54][55] made from various biomaterials may have applications [56][57][58][59][60][61][62] in DDSs, and 2PP has been evaluated as a tool for development of DDSs. Chan et al [63] used 2PP to deposit complex protein microstructures with submicrometer features and controllability.…”

Section: Two-photon Polymerization Technology For Tissue Engi-mentioning

confidence: 99%

3D Nanoprinting Technologies for Tissue Engineering Applications

Lee

2015

Journal of Nanomaterials

View full text Add to dashboard Cite

Tissue engineering recovers an original function of tissue by replacing the damaged part with a new tissue or organ regenerated using various engineering technologies. This technology uses a scaffold to support three-dimensional (3D) tissue formation. Conventional scaffold fabrication methods do not control the architecture, pore shape, porosity, or interconnectivity of the scaffold, so it has limited ability to stimulate cell growth and to generate new tissue. 3D printing technologies may overcome these disadvantages of traditional fabrication methods. These technologies use computers to assist in design and fabrication, so the 3D scaffolds can be fabricated as designed and standardized. Particularly, because nanofabrication technology based on two-photon absorption (2PA) and on controlled electrospinning can generate structures with submicron resolution, these methods have been evaluated in various areas of tissue engineering. Recent combinations of 3D nanoprinting technologies with methods from molecular biology and cell dynamics have suggested new possibilities for improved tissue regeneration. If the interaction between cells and scaffold system with biomolecules can be understood and controlled and if an optimal 3D environment for tissue regeneration can be realized, 3D nanoprinting will become an important tool in tissue engineering.

show abstract

Drug Delivery Systems for the Treatment of Diabetes Mellitus: State of the Art

Cited by 9 publications

References 0 publications

Inhaled insulin: A “puff” than a “shot” before meals

Inhaled insulin: A “puff” than a “shot” before meals

Food biotechnology

3D Nanoprinting Technologies for Tissue Engineering Applications

Contact Info

Product

Resources

About