Drug delivery nanoplatform for orthopaedic-associated infections

Tsiapla, Aikaterini-Rafailia; Karagkiozaki, V.; Pappa, F.; Bakola, V.; Choli-Papadopoulou, Th.; Moutsios, Ioannis; Pavlidou, E.; Laskarakis, A.; Logothetidis, S.

doi:10.1016/j.matpr.2017.07.017

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…9 combined in a stepwise nested approach risk assessment, LCA and Socio-Economic Analysis (SEA) to support the SSbD efforts. The authors implemented the Cooper's Stage-Gate model which was also proposed by the pioneers of the SbD iterative approach in nanosafety (NanoReg2) [10][11][12][13] proposed a semi-quantitative methodology grounded on the combination of S-LCA and multi-criteria decision analysis (MCDA) methods to support the initial screening and decision making upon socio-economic impacts over the life cycle of a product at each stage gate of the innovation process. The application of their methodology is a scoring procedure (Excel based self-assessment tool) to facilitate its uptake by industries.…”

Section: The Ssbd Frameworkmentioning

confidence: 99%

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

et al. 2023

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Section: The Ssbd Frameworkmentioning

confidence: 99%

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

et al. 2023

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“…Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. implant technology to create novel and more efficient implants that can release therapeutic agents at the site of the pathogenic area [5,6]. Therefore, coronary drug-eluting stents (DESs) were developed, as a vehicle of local drug administration, to reduce the possibility of late stent thrombosis and restenosis that are the most common drawbacks of stenting [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Dipyridamole-loaded biodegradable PLA nanoplatforms as coatings for cardiovascular stents

et al. 2018

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Cardiovascular stents are commonly used for the treatment of cardiovascular diseases that in developed societies are the most frequent causes of mortality and morbidity. In recent years, thorough research and development of drug-eluting stents has been done, with emphasis on coronary stenting to avoid the most common complication, in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug delivery nanoplatforms consisting of biodegradable polymers can be fabricated via electrospinning deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds that are able to sustain and control drug release. A novel drug delivery nanosystem of polylactic acid fibrous scaffold loaded with the anti-platelet drug DPM was fabricated by electrospinning as coating for cardiovascular stents. The surface morphology and topography that were evaluated via atomic force microscopy, scanning electron microscopy and optical microscopy, were found to be good and suitable for tissue engineering. Contact angle measurements established the hydrophobic behavior of these fibrous nanoplatforms. Drug-release kinetics and degradation studies were conducted and revealed a sustained and controllable release of DPM, through this fibrous matrix over time. Finally, cytotoxicity studies took place to evaluate the cytocompatibility of the scaffold that confirmed its compatible behavior. The successful performance of this nanoplatform can lead to it being a valuable tool for atherosclerosis treatment.

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“…It should be mentioned that such electrospun scaffolds are a very promising approach for the regeneration and repair of bones and related tissue [7] in total hip replacement or bone-fracture repair. The number of patients in need of such surgeries is envisaged to increase rapidly either as the people get older or due to car accidents [8–10]. All bone substitute materials must be bioactive and behave similarly to healthy bones [11].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

Tsiapla¹,

Karagkiozaki²,

Bakola³

et al. 2018

Beilstein J. Nanotechnol.

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There is, as a matter of fact, an ever increasing number of patients requiring total hip replacement (Pabinger, C.; Geissler, A. Osteoarthritis Cartilage 2014, 22, 734–741). Implant-associated acute inflammations after an invasive orthopedic surgery are one of the major causes of implant failure. In addition, there are instability, aseptic loosening, infection, metallosis and fracture (Melvin, J. S.; Karthikeyan, T.; Cope, R.; Fehring, T. K. J. Arthroplasty 2014, 29, 1285–1288). In this work, a drug-delivery nanoplatform system consisting of polymeric celluloce acetate (CA) scaffolds loaded with dexamethasone was fabricated through electrospinning. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) indicated the successful fabrication of these structures. Cytotoxicity studies were performed by using MTT assay, methylene-blue staining and SEM fixation and showed very good cell adhesion and proliferation, indicating the cytocompatibility of these fibrous scaffolds. Drug-release kinetics was measured for the evaluation of a controllable and sustained release of anti-inflammatory drug onto the engineered implants and degradation study was conducted in order to assess the mass loss of polymers. This drug-delivery nanoplatform as coating on titanium implants may be a promising approach not only to alleviate but also to prevent implant-associated acute inflammations along with a simultaneous controlled release of the drug.

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Drug delivery nanoplatform for orthopaedic-associated infections

Cited by 6 publications

References 15 publications

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Dipyridamole-loaded biodegradable PLA nanoplatforms as coatings for cardiovascular stents

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

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