Drug delivery from gold and titanium surfaces using self-assembled monolayers

Mani, Gopinath; Johnson, David R.; Marton, D.; Feldman, Marc D.; Patel, D.J.; Ayón, Arturo A.; Agrawal, C. Mauli

doi:10.1016/j.biomaterials.2008.08.014

Cited by 96 publications

(90 citation statements)

References 49 publications

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“…10 Surface modification using SAMs is one of the promising techniques for delivering drugs from metal implants without polymeric carriers. 22,23 Our previous studies have shown that a model drug ͑flufenamic acid͒ can be released from model substrates ͑gold and titanium͒ for a period of 4 weeks using SAMs. 22 The amount of drug coated using SAMs was ϳ100 ng/ cm 2 .…”

Section: Discussionmentioning

confidence: 99%

“…22,23 Our previous studies have shown that a model drug ͑flufenamic acid͒ can be released from model substrates ͑gold and titanium͒ for a period of 4 weeks using SAMs. 22 The amount of drug coated using SAMs was ϳ100 ng/ cm 2 . 22 The drug release showed an initial burst followed by a slow release.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we successfully demonstrated the use of selfassembled monolayers ͑SAMs͒ as a polymer-free drug delivery platform for stents with no adverse response from endothelial cells. 22,23 However, some technical challenges remained in the use of SAMs as an effective drug delivery platform for stents. The objectives of this study are to overcome the technical challenges listed below.…”

Section: Introductionmentioning

confidence: 99%

“…First, our previous studies were carried out using model substrates ͑gold and titanium͒ and a model drug ͑flufenamic acid͒. 22 Hence, the first objective of this study is to adapt SAM based platform to release an antiproliferative drug ͓paclitaxel ͑PAT͔͒ from a stent material ͓cobalt-chromium ͑Cou Cr͒ alloy͔. Second, the amount of drug that was coated using SAMs was in ng/ cm 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Second, the amount of drug that was coated using SAMs was in ng/ cm 2 . 22 Hence, the second objective of this study is to increase the amount of drug coated using SAM platform to levels comparable to those employed in currently available DES ͑in g / cm 2 ͒.…”

Section: Introductionmentioning

confidence: 99%

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Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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Polymer-based platforms in drug-eluting stents ͑DESs͒ can cause adverse reactions in patients. Hence, the development of a polymer-free drug delivery platform may reduce adverse reactions to DES. In this study, the use of a polymer-free platform, self-assembled monolayers ͑SAMs͒, is explored for delivering an antiproliferative drug ͓paclitaxel ͑PAT͔͒ from a stent material ͓cobalt-chromium ͑͑Cou Cr͒ alloy͔. Initially, carboxylic acid terminated phosphonic acid SAMs were coated on Cou Cr alloy. Two different doses ͑25 and 100 g / cm 2 ͒ of PAT were coated on SAM coated Cou Cr surfaces using a microdrop deposition method. Also, control experiments were carried out to coat PAT directly on Cou Cr surfaces with no SAM modification. The PAT coated specimens were characterized using the Fourier transform infrared spectroscopy ͑FTIR͒, scanning electron microscopy ͑SEM͒, and atomic force microscopy ͑AFM͒. FTIR spectra showed the successful deposition of PAT on SAM coated and control-Cou Cr surfaces. SEM images showed islands of high density PAT crystals on SAM coated surfaces, while low density PAT crystals were observed on control-Cou Cr alloy. AFM images showed molecular distribution of PAT on SAM coated as well as control-Cou Cr alloy surfaces. In vitro drug release studies showed that PAT was released from SAM coated Cou Cr surfaces in a biphasic manner ͑an initial burst release in first 7 days was followed by a slow release for up to 35 days͒, while the PAT was burst released from control-Cou Cr surfaces within 1-3 days. Thus, this study demonstrated the use of SAMs for delivering PAT from Cou Cr alloy surfaces for potential use in drug-eluting stents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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Advanced Titanium Surfaces and Its Alloys for Orthopedic and Dental Applications Based on Digital SEM Imaging Analysis

Fadlallah

Ashour

Dey³

2016

Advanced Surface Engineering Materials

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Surface‐Mediated Stimuli Responsive Delivery of Organic Molecules from Porous Carriers to Adhered Cells

Ergün

Cola

Galla

et al. 2016

Adv Healthcare Materials

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The alternating layer-by-layer deposition of oppositely charged polyelectrolytes on fluorescence-dye-(Hst)-loaded zeolites L ((Hst) Zeo-PSS/PLL) is described. The arrays and nanocomposite (NC) hydrogels of (Hst) Zeo-PSS/PLL are prepared. The subsequent cell experiments show the potential application of arrays and NC hydrogels of (Hst) Zeo-PSS/PLL as alternative 2D- and 3D-surfaces, respectively, for 2D- and 3D-surface-mediated controlled organic molecules delivery applications.

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Drug delivery from gold and titanium surfaces using self-assembled monolayers

Cited by 96 publications

References 49 publications

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Advanced Titanium Surfaces and Its Alloys for Orthopedic and Dental Applications Based on Digital SEM Imaging Analysis

Surface‐Mediated Stimuli Responsive Delivery of Organic Molecules from Porous Carriers to Adhered Cells

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