Drug Delivery for Cancer Immunotherapy and Vaccines

Batty, Cole J.; Tiet, Pamela; Bachelder, Eric M.; Ainslie, Kristy M.

doi:10.2174/2211738506666180918122337

Cited by 19 publications

(15 citation statements)

References 115 publications

(153 reference statements)

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“…This has led to over 20 vaccine candidates in clinical trials and over 140 more in preclinical evaluation, made by almost as many developers. [ 25,141 ] Vaccines developed for a pandemic seem to be an exception for otherwise low profitability, as $3.3 billion in sales accompanied vaccines made in 2009 during the H1N1 influenza pandemic. [ 142 ] A first‐to‐market vaccine can carry the advantage of gaining the largest contracts, which was seen with Novartis’ H1N1 influenza vaccine in the US during the 2009 pandemic.…”

Section: Considerations For Polymeric Particle Manufacturingmentioning

confidence: 99%

“…Several particle‐based vaccines for COVID‐19, such as lipid complexes and VLPs, are also in development. [ 25,141 ] Whether the current pandemic environment will garner advances for polymeric particle vaccines is still yet to be determined.…”

Section: Considerations For Polymeric Particle Manufacturingmentioning

confidence: 99%

“…Indeed, the two leading vaccine candidates for the COVID-19 pandemic, developed by Moderna and Pfizer/BioNTech, are a lipid nanoparticle (NP) that complexes mRNA encoding the SARS-CoV-2 spike protein. [23][24][25] If approved, COVID-19-based vaccines would be the first nucleic acid vaccines to be approved by the FDA. At the time of writing this review, Pfizer/BioNTech has been approved for application in the United Kingdom [26] and Moderna has filed for emergency FDA approval of their vaccine.…”

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confidence: 99%

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Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases

Genito

Batty

Bachelder

et al. 2021

Advanced NanoBiomed Research

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Vaccines have advanced human health for centuries. To improve upon the efficacy of subunit vaccines they have been formulated into nano/microparticles for infectious diseases. Much progress in the field of polymeric particles for vaccine formulation has been made since the push for a tetanus vaccine in the 1990s. Modulation of particle properties such as size, surface charge, degradation rate, and the co‐delivery of antigen and adjuvant has been used. This review focuses on advances in the understanding of how these properties influence immune responses to injectable polymeric particle vaccines. Consideration is also given to how endotoxin, route of administration, and other factors influence conclusions that can be made. Current manufacturing techniques involved in preserving vaccine efficacy and scale‐up are discussed, as well as those for progressing polymeric particle vaccines toward commercialization. Consideration of all these factors should aid the continued development of efficacious and marketable polymeric particle vaccines.

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Section: Considerations For Polymeric Particle Manufacturingmentioning

confidence: 99%

Section: Considerations For Polymeric Particle Manufacturingmentioning

confidence: 99%

mentioning

confidence: 99%

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Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases

Genito

Batty

Bachelder

et al. 2021

Advanced NanoBiomed Research

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“…To develop novel therapeutic materials for combination therapy against cancer, nanoscience can be of great help [40, 41]. Since nanocarriers can carry appropriate molecules, it would be beneficial to combine new therapeutic molecule for delivery of those molecules to tumor for more complex trials [40–44].…”

Section: Discussionmentioning

confidence: 99%

Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis

Xu¹,

Zhang²,

Park³

et al. 2019

j. immunotherapy cancer

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Background Efficient cancer therapy is sought not only for primary tumor treatment but also for the prevention of metastatic cancer growth. Immunotherapy has been shown to prevent cancer metastasis by inducing antigen-specific immune responses. Indocyanine green (ICG) has a peak spectral absorption at about 800 nm, which makes it a photothermal reagent for direct treatment of solid tumors by photothermal therapy (PTT). Since PTT alone cannot fully induce antigen-specific immune response for prevention of cancer metastasis, the combination of PTT and immunotherapy has been developed as a new strategy of cancer treatment. Methods Thermal responsive liposomes (TRL) were synthesized by incorporating ICG into the lipid bilayer and encapsulating the water-soluble immune stimulatory molecule polyinosinic:polycytidylic acid (poly I:C) in the hydrophilic core. The poly I:C- and ICG-containing TRLs (piTRLs) were analyzed according to size, and their photothermal effect was evaluated following laser irradiation at 808 nm. Moreover, the temperature-dependent release of poly I:C was also measured. For cancer therapy, CT-26 (carcinoma) and B16 (melanoma) cells were subcutaneously inoculated to build the 1st transplanted tumor in BALB/c and C57BL/6 mice, respectively. These mice received a 2nd transplantation with the same cancer cells by intravenous inoculation, for evaluation of the anti-metastatic effects of the liposomes after PTT. Results Near-infrared (NIR) laser irradiation increased the temperature of piTRLs and effectively released poly I:C from the liposomes. The increased temperature induced a photothermal effect, which promoted cancer cell apoptosis and dissolution of the 1st transplanted tumor. Moreover, the released poly I:C from the piTRL induced activation of dendritic cells (DCs) in tumor draining lymph node (tdLN). Cancer cell apoptosis and DC-activation-mediated cancer antigen-specific immune responses further prevented growth of lung metastatic cancer developed following intravenous transplantation of cancer cells. Conclusion These results demonstrated the potential usage of a piTRL with laser irradiation for immuno-photothermal therapy against various types of cancer and their metastases. Electronic supplementary material The online version of this article (10.1186/s40425-019-0702-1) contains supplementary material, which is available to authorized users.

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“…Virus-like particles are nano sized but mimic the associated molecular pattern, they can be easily customized for specific peptide load delivery and can be modulated as effective adjuvant action to increase immunization efficacy. Previously it efficiently served as a vehicle for drug/vaccine in immunotherapies and cancer [ 260 ]. Therefore, these nanotechnologies guided peptide delivery mechanism may be potentiated more efficiently and rapid remedial.…”

Section: Cellular Pathways Triggered By Sars-cov-2mentioning

confidence: 99%

Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view

Chatterjee

Mishra

Chowdhury³

et al. 2021

Life Sciences

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COVID-19 pandemic is still a major risk to human civilization. Besides the global immunization policy, more than 5lac new cases are documented every day. Some countries newly implement partial/complete nationwide lockdown to mitigate recurrent community spreading. To avoid the new modified stain of SARS-CoV-2 spreading, some countries imposed any restriction on the movement of the citizens within or outside the country. Effective economical point of care diagnostic and therapeutic strategy is vigorously required to mitigate viral spread. Besides struggling with repurposed medicines, new engineered materials with multiple unique efficacies and specific antiviral potency against SARS-CoV-2 infection may be fruitful to save more lives. Nanotechnology-based engineering strategy sophisticated medicine with specific and effective, the nonhazardous delivery mechanism for available repurposed antivirals as well as remedial for associated diseases due to malfeasance in immuno-system e.g. hypercytokinaemia, acute respiratory distress syndrome. This review will talk about gloomy but critical areas for nanoscientists to intervene and will showcase about the different laboratory diagnostic, prognostic strategies and their mode of actions. In addition, we speak about SARS-CoV-2 pathophysiology, pathogenicity and interaction with the host with special emphasis on altered immuno-system and also perceptualized, copious ways to design prophylactic nanomedicines and next-generation vaccines based on recent findings.

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Drug Delivery for Cancer Immunotherapy and Vaccines

Cited by 19 publications

References 115 publications

Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases

Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases

Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis

Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view

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