Drug delivery dressings

Matthews, Kerr H.

doi:10.1533/9780857093301.3.361

Cited by 9 publications

(3 citation statements)

References 122 publications

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“…These materials vary in absorbency and can cause injury and incomplete tissue growth upon removal. 4,5 Therefore, there is a need for biodegradable wound dressings based on bioactive materials that can induce wound healing and promote the deposition of extracellular matrix (ECM). 6 Natural polymers are increasingly being used due to their biocompatibility, low immunogenicity, and clinical functions compared to synthetic polymers.…”

Section: Introductionmentioning

confidence: 99%

“…Traditional dressings primarily consist of lint, cotton wool, and synthetic and natural gauzes and bandages. These materials vary in absorbency and can cause injury and incomplete tissue growth upon removal 4,5 . Therefore, there is a need for biodegradable wound dressings based on bioactive materials that can induce wound healing and promote the deposition of extracellular matrix (ECM) 6 .…”

Section: Introductionmentioning

confidence: 99%

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Development of wound dressing materials based on silk fibroin and transgenic silk fibroin with Arg‐Gly‐Asp motifs

Asakura,

Kitayama,

Naito

2024

J of Applied Polymer Sci

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In this paper, wound dressing materials made of silk fibroin (SF) and transgenic SF with Arg‐Gly‐Asp motifs (TG‐RGD SF) were developed. Initially, an animal evaluation experiment with mice to demonstrate the usefulness of SF film as a wound dressing was performed. The amorphous SF film was shown to promote the formation of granulation tissue and neovessels in the dermis, leading to skin regeneration. As a result, amorphous SF film is suitable for use as a wound dressing materials. Then, the SF‐ Human umbilical vein endothelial cells signaling pathway was determined by cell proliferation assay with pharmacological inhibitors. Subsequently, a mice evaluation experiment to assess the promotion of healing effects using TG‐RGD SF was conducted and the results were compared with those obtained using SF. In the wound area evaluation and the quantitative evaluation of granulation tissue formation, the TG‐RGD SF film promoted dermis regeneration more than the SF film.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of wound dressing materials based on silk fibroin and transgenic silk fibroin with Arg‐Gly‐Asp motifs

Asakura,

Kitayama,

Naito

2024

J of Applied Polymer Sci

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“…Given the premises that hydrogels enable large amounts of bioactive molecules to be loaded into the polymeric network, they permit controlled release at the desired site as the hydrogels are placed directly at the targeted location (like a dressing or injectable/in situ gelling material), and the drug release occurs through a specific mechanism or strategy (swelling, network relaxation, temperature-induced transition, etc. ), it can be hypothesized that hydrogels can be used as dressings able to perform controlled drug delivery [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

et al. 2020

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The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

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