“…Much has changed since ancient Egyptian physician viewed spinal injury "an ailment not be treated" [1,].More than 250,000 Americans currently suffer from the consequence of spinal cord injury(SCI) and,with an annual incidence of 40 cases per million population, over 11,000 new cases of SCI occur in the United States each year [2,].About one third of SCI patients develop infection during hospitalization, with an overall incidence of 35 episodes of hospital acquired infection/1000 hospital days [3].SCI are most often caused by physical trauma [4].In the US, Motor Vehicle accidents are most common cause of SCIs; second are falls, then violence such as gunshot wounds, then sports injuries [5].Other causes of SCIs include, attempted suicide, military conflicts, and iatrogenic injury, caused by an improperly done medical procedures such as an injection into spinal column [6][7][8].In Malaysia motor vehicle accidents(66%) and falls(28%) are the main cause of SCIs [9].Most infections that occur in SCI patients also affect able-bodied patient, but the frequency and clinical characteristics of infections vary between those populations. Whereas urinary tract infections are the most common [10],pneumonia has the highest infection-associated mortality [11],and infections of pressure sores and underlying bone are probably most difficult to manage [12].Contributory factors to SCIinfection include, frequent insertion of urologic, vascular, orthopedic, respiratory ,gastrointestinal, and neurosurgical devices predispose to various prosthesis-related infections [3].Infection frequently manifests differently in the SCI population than in able-bodied individuals.…”