Drug Delivery: ATP‐Responsive Aptamer‐Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs (Adv. Funct. Mater. 37/2017)

Chen, Wei‐Hai; Xu, Yan; Liao, Weizhi; Sohn, Yang Sung; Cecconello, Alessandro; Kozell, Anna; Nechushtai, Rachel; Willner, Itamar

doi:10.1002/adfm.201770220

Cited by 12 publications

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“…Willner and coworkers recently extended this nucleic acid conjugation strategy to prepare ATP-responsive aptamer-based nMOFs for the controlled release of chemotherapeutics. [88] They loaded doxorubicin to the channels of Zr-amino-triphenyldicarboxylate nMOF that was previously reported by Lin and coworkers, [80, 89] and then capped the loaded nMOF by hybridization with a complementary nucleic acid, the ATP-aptamer or the ATP-AS1411 hybrid aptamer, in caged configurations. The nMOFs are unlocked in the presence of ATP via the formation of ATP-aptamer complexes to release the drug payloads.…”

Section: Nmofs For Therapeutic Applicationsmentioning

confidence: 99%

“…[87, 89, 134, 135] Zhang and coworkers recently reported cancer cell membrane-camouflaged nMOF nanocomposites to evade the MPS, but this coating increased particle size, thereby causing lung accumulation. [123] In addition, nMOFs have also been modified with various targeting moieties such as folates, [158] integrin-targeting peptides, [51, 73] and aptamers, [88, 194] to increase their uptake in cancer cells. Despite significance progress in surface modifications and active targeting of nMOFs, accurate characterization of coating/targeting efficiency and stability is still an unsolved challenge.…”

Section: Fundamental Challenges and Outlookmentioning

confidence: 99%

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Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

et al. 2018

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Nanotechnology has played an important role in drug delivery and biomedical imaging over the past two decades. In particular, nanoscale metal-organic frameworks (nMOFs) are emerging as an important class of biomedically relevant nanomaterials due to their high porosity, multifunctionality, and biocompatibility. The high porosity of nMOFs allows for the encapsulation of exceptionally high payloads of therapeutic and/or imaging cargoes while the building blocks-both ligands and the secondary building units (SBUs)-can be utilized to load drugs and/or imaging agents via covalent attachment. The ligands and SBUs of nMOFs can also be functionalized for surface passivation or active targeting at overexpressed biomarkers. The metal ions or metal clusters on nMOFs also render them viable candidates as contrast agents for magnetic resonance imaging, computed tomography, or other imaging modalities. This review article summarizes recent progress on nMOF designs and their exploration in biomedical areas. First, the therapeutic applications of nMOFs, based on four distinct drug loading strategies, are discussed, followed by a summary of nMOF designs for imaging and biosensing. The review is concluded by exploring the fundamental challenges facing nMOF-based therapeutic, imaging, and biosensing agents. This review hopefully can stimulate interdisciplinary research at the intersection of MOFs and biomedicine.

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Section: Nmofs For Therapeutic Applicationsmentioning

confidence: 99%

Section: Fundamental Challenges and Outlookmentioning

confidence: 99%

Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

et al. 2018

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“…Not surprisingly, the switchable structural and functional properties of nucleic acids provide a means to develop DNA switches, DNA‐based machines, DNA‐based triggered drug carriers, such as drug‐loaded SiO 2 nanoparticles or microcapsules, programmed reconfiguration of DNA nanostructures, such as origami nanostructures, a well as the triggered reversible aggregation/disaggregation of NPs . Different applications of switchable DNA structures and catalytic nucleic acid assemblies have been suggested, including the development of sensors, controlled drug release from nanocarriers, and the design of chiroplasmonic structures…”

Section: Stimuli‐responsive Dna‐based Hydrogelsmentioning

confidence: 99%

Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications

2020

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This Review presents polysaccharides, oligosaccharides, nucleic acids, peptides, and proteins as functional stimuli‐responsive polymer scaffolds that yield hydrogels with controlled stiffness. Different physical or chemical triggers can be used to structurally reconfigure the crosslinking units and control the stiffness of the hydrogels. The integration of stimuli‐responsive supramolecular complexes and stimuli‐responsive biomolecular units as crosslinkers leads to hybrid hydrogels undergoing reversible triggered transitions across different stiffness states. Different applications of stimuli‐responsive biomolecule‐based hydrogels are discussed. The assembly of stimuli‐responsive biomolecule‐based hydrogel films on surfaces and their applications are discussed. The coating of drug‐loaded nanoparticles with stimuli‐responsive hydrogels for controlled drug release is also presented.

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“…Both approaches allow for various ATP‐triggered hierarchical structure formation processes due to the abundant availability of building blocks from the fields of supramolecular chemistry, peptide nanoscience, and DNA/RNA nanotechnology. [ 21,56,58,82 ] However, often such systems show limited selectivity toward ATP over other ATP analogues such as ADP, AMP, GTP, CTP, and UTP. In enzymatic systems, ATP‐dependent reactions are extremely sensitive to the exclusive use of ATP, such as for DNA and RNA ligases, as well as for protein kinases.…”

Section: Molecular Mechanisms For the Integration Of Atp In Self‐assementioning

confidence: 99%

ATP‐Responsive and ATP‐Fueled Self‐Assembling Systems and Materials

2020

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his/her body weight in ATP each day, which is enabled through a very efficient ADP/ATP recycling system. [7] Aside of the fascinating non-equilibrium succeeded by exploiting ATP/GTP as chemical fuels to drive structures and functions, it is also important to realize that ATP and other nucleoside phosphates can be used as biological and chemical signals. [8-10] Lots of biological processes such as chromatin remodeler activation, [11] inflammatory signaling, [12] and cell differentiation [13] are mediated by ATP signaling. Additionally, cancer cells have a higher concentration of ATP, [14] which in turn provides a handle to develop new types of molecular therapies. This of course requires to develop sophisticated carriers or self-assembling structures that highly specifically react to ATP and potentially even to its concentration, ideally without any interference from other nucleoside phosphates. [15-20] For such cases, it is also important to realize that ATP is used as a chemical signal rather than a chemical fuel, as the primary objective may not be to harvest its energy from hydrolysis for functions, but just to use its chemical structure for a change of function. Overall, it becomes clear that the use of ATP (and similarly GTP) as a trigger or as a chemical fuel is of high relevance to interact with living systems and also to be able to create active devices in long term that can create work and allow for active communication in a biological environment using the fuels available therein. [21] In the scope of this review on ATP-dependent systems, and being set at the interface of near-equilibrium responsive materials versus non-equilibrium active materials, it is useful to begin Adenosine triphosphate (ATP) is a central metabolite that plays an indispensable role in various cellular processes, from energy supply to cell-tocell signaling. Nature has developed sophisticated strategies to use the energy stored in ATP for many metabolic and non-equilibrium processes, and to sense and bind ATP for biological signaling. The variations in the ATP concentrations from one organelle to another, from extracellular to intracellular environments, and from normal cells to cancer cells are one motivation for designing ATPtriggered and ATP-fueled systems and materials, because they show great potential for applications in biological systems by using ATP as a trigger or chemical fuel. Over the last decade, ATP has been emerging as an attractive co-assembling component for man-made stimuli-responsive as well as for fuel-driven active systems and materials. Herein, current advances and emerging concepts for ATP-triggered and ATP-fueled self-assemblies and materials are discussed, shedding light on applications and highlighting future developments. By bringing together concepts of different domains, that is from supramolecular chemistry to DNA nanoscience, from equilibrium to nonequilibrium self-assembly, and from fundamental sciences to applications, the aim is to cross-fertilize current approaches with the ultimate aim to bring ...

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Drug Delivery: ATP‐Responsive Aptamer‐Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs (Adv. Funct. Mater. 37/2017)

Cited by 12 publications

References 0 publications

Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

Nanoscale Metal–Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications

ATP‐Responsive and ATP‐Fueled Self‐Assembling Systems and Materials

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