Drug delivery and controlled release from biocompatible metal–organic frameworks using mechanical amorphization

Orellana-Tavra, Claudia; Marshall, Ross J.; Baxter, Emma F.; Lázaro, Isabel Abánades; Tao, Andi; Cheetham, Anthony K.; Forgan, Ross S.; Fairen‐Jimenez, David

doi:10.1039/c6tb02025a

Cited by 145 publications

(139 citation statements)

References 60 publications

(66 reference statements)

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“…Previously, we and others have shown that UiO‐66 is biocompatible, while the cytotoxicity of DCA ‐loaded MOFs is dependent on surface chemistry, and incorporation of a second drug can dramatically enhance overall cytotoxicity . As well as DCA , we have chosen α‐cyano‐4‐hydroxycinnamic acid ( α‐CHC ), a molecule recently proposed as an anticancer agent, due to the relatively low p K a of its carboxylate unit (2.2), comparable with the one of DCA (1.4).…”

Section: Resultsmentioning

confidence: 99%

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

2020

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Metal–organic frameworks (MOFs) are emerging as leading candidates for nanoscale drug delivery, as a consequence of their high drug capacities, ease of functionality, and the ability to carefully engineer key physical properties. Despite many anticancer treatment regimens consisting of a cocktail of different drugs, examples of delivery of multiple drugs from one MOF are rare, potentially hampered by difficulties in postsynthetic loading of more than one cargo molecule. Herein, we report a new strategy, multivariate modulation, which allows incorporation of up to three drugs in the Zr MOF UiO‐66 by defect‐loading. The drugs are added to one‐pot solvothermal synthesis and are distributed throughout the MOF at defect sites by coordination to the metal clusters. This tight binding comes with retention of crystallinity and porosity, allowing a fourth drug to be postsynthetically loaded into the MOFs to yield nanoparticles loaded with cocktails of drugs that show enhancements in selective anticancer cytotoxicity against MCF‐7 breast cancer cells in vitro. We believe that multivariate modulation is a significant advance in the application of MOFs in biomedicine, and anticipate the protocol will also be adopted in other areas of MOF chemistry, to easily produce defective MOFs with arrays of highly functionalised pores for potential application in gas separations and catalysis.

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Section: Resultsmentioning

confidence: 99%

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

2020

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“…In this case, The MOF structures have been loaded with fluorescent molecules (e.g., calcein), and demonstrated the use of mechanical amorphisation processes for the controlled delivery of the guest molecules (Figure 15). The research results showed that the fine balance between the material's pores and the guest molecules is crucial for achieving effective release of the guest molecules [87]. …”

Section: Drug Delivery Systems (Dds)mentioning

confidence: 99%

Self-Assembly in Polyoxometalate and Metal Coordination-Based Systems: Synthetic Approaches and Developments

et al. 2018

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Abstract:Utilizing new experimental approaches and gradual understanding of the underlying chemical processes has led to advances in the self-assembly of inorganic and metal-organic compounds at a very fast pace over the last decades. Exploitation of unveiled information originating from initial experimental observations has sparked the development of new families of compounds with unique structural characteristics and functionalities. The main source of inspiration for numerous research groups originated from the implementation of the design element along with the discovery of new chemical components which can self-assemble into complex structures with wide range of sizes, topologies and functionalities. Not only do self-assembled inorganic and metal-organic chemical systems belong to families of compounds with configurable structures, but also have a vast array of physical properties which reflect the chemical information stored in the various "modular" molecular subunits. The purpose of this short review article is not the exhaustive discussion of the broad field of inorganic and metal-organic chemical systems, but the discussion of some representative examples from each category which demonstrate the implementation of new synthetic approaches and design principles.

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“…Second, MOFs are intrinsically biodegradable as a result of relatively labile metal–ligand bonds, making it possible to rapidly degrade and clear the nanocarriers after the intended task is completed (Rocca, Liu, & Lin, ). Though the moderately low chemical and aqueous stability of MOFs has limited their scope for industrial applications, this drawback of MOFs is considered an advantage for delivery system in light industry or medicine applications, as the MOF particles can be biodegraded and eliminated from the body after the compounds are released (Orellana‐Tavra et al, ). At present, there are some studies of MOFs used as nanocarriers for drug delivery (ibuprofen [Erucar & Keskin, ], alendronate [Golmohamadpour, Bahramian, Shafiee, & Mamani, ], doxorubicin hydrochloride [Bhattacharjee et al, ]), VOC removal (Xu et al, ; Zhang, Lv, Shi, Yang, & Yang, ; Zhu, Hu, Tong, Zhao, & Zhao, ), and sustained release of small molecule dyes (Li et al, ) and cosmetic molecules (caffeine and urea; Erucar & Keskin, ).…”

Section: Introductionmentioning

confidence: 99%

“…One well‐recognized challenge of MOFs is their poor aqueous stability, limiting their scope for practical applications. However, this drawback of MOFs is considered an advantage for delivery system in food industry or biomedicine applications, as the MOF particles can be biodegraded and eliminated from the body after the volatile compounds are released (Orellana‐Tavra et al, ).…”

Section: Introductionmentioning

confidence: 99%

Adsorption and controlled release of three kinds of flavors on UiO‐66

Mao

Xie

et al. 2020

Food Science & Nutrition

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Delivery systems for controlled release of fragrances are significantly essential in the flavor and fragrance industry due to a limited life span (premature evaporation and degradation) of fragrance compounds. Recently, several adsorption materials such as porous materials have been developed in delivery systems for targeted fragrance release. In this work, UiO-66, a member of metal-organic framework (MOF) family with high porosity and greater adsorbability, was selected as a prospective alternative to traditional porous adsorbents for controlled release of fragrances. Isophorone, eugenol, and β-ionone with strong aroma are widely used as perfume flavors, soap flavor, cosmetic flavors, and even as a food-flavoring agents, and were chosen as representative fragrances for adsorption and controlled release studies. The adsorption and release behavior of fragrances on UiO-66 was evaluated by high-performance liquid chromatography (HPLC). The UiO-66 with high surface area (1,076 m 2 /g) achieved effective storage and controlled release for isophorone, eugenol, and β-ionone. The adsorption rates of isophorone, eugenol, and β-ionone can reach 99.4%, 99.9%, and 60.2%, respectively. Additionally, the release of these fragrances from UiO-66 can sustain over 20 days. UiO-66 exhibited higher release rate over eugenol with desorption rates of 95.2% than that of β-ionone (52.6%) and isophorone (49.6%), respectively, suggesting a good adsorption-release selectivity of UiO-66 to different fragrances. This study further confirms the usability of UiO-66 in fragrance release and extends the application of MOF porosity in aroma release. K E Y W O R D S adsorption and controlled release, eugenol, isophorone, UiO-66, β-ionone S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Mao D, Xie C, Li Z, et al. Adsorption and controlled release of three kinds of flavors on UiO-66.

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Drug delivery and controlled release from biocompatible metal–organic frameworks using mechanical amorphization

Abstract: We have used a family of Zr-based metal–organic frameworks (MOFs) with different functionalized (bromo, nitro and amino) and extended linkers for drug delivery.

Cited by 145 publications

References 60 publications

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

Self-Assembly in Polyoxometalate and Metal Coordination-Based Systems: Synthetic Approaches and Developments

Adsorption and controlled release of three kinds of flavors on UiO‐66

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