Drug Delivery

Lavik, Erin B.; Kuppermann, Baruch D.; Humayun, Mark S.

doi:10.1016/b978-1-4557-0737-9.00038-2

Cited by 19 publications

(8 citation statements)

References 114 publications

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“…The sequence of the drug delivery process includes administration of the dosage form, release of the Active Pharmaceutical Ingredient (API) from the dosage form, and transport of API across the biological membrane through the blood to the site of action/ target site 9 .…”

Section: Fig 2: List Of Biopharmaceuticals As Per European Pharmacopeiamentioning

confidence: 99%

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Untitled

2021

IJPSR

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Section: Fig 2: List Of Biopharmaceuticals As Per European Pharmacopeiamentioning

confidence: 99%

“…Apart from all these, drug carrier systems like liposomes, emulsions, Nanoemulsions, microparticles, Niosomes are used to deliver the drug by enhancing the bioavailability 9,17 . Some of the examples are stated in Table 1.…”

Section: Nasal Ddsmentioning

confidence: 99%

Untitled

2021

IJPSR

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“…The compounds are mainly pharmaceutical in nature and targeted against a particular disease condition to a particular cell population in vivo. The term drug delivery encompasses two main ideas: form of dosage and route of administration [ 1 ]. Proper drug delivery ensures efficient drug activity by regulating the following: drug release, absorption by cells and correct distribution within the system [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery

Saleem

Kannan

2021

Nanoscale Res Lett

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Delivering drugs to the brain has always remained a challenge for the research community and physicians. The blood–brain barrier (BBB) acts as a major hurdle for delivering drugs to specific parts of the brain and the central nervous system. It is physiologically comprised of complex network of capillaries to protect the brain from any invasive agents or foreign particles. Therefore, there is an absolute need for understanding of the BBB for successful therapeutic interventions. Recent research indicates the strong emergence of zebrafish as a model for assessing the permeability of the BBB, which is highly conserved in its structure and function between the zebrafish and mammals. The zebrafish model system offers a plethora of advantages including easy maintenance, high fecundity and transparency of embryos and larvae. Therefore, it has the potential to be developed as a model for analysing and elucidating the permeability of BBB to novel permeation technologies with neurospecificity. Nanotechnology has now become a focus area within the industrial and research community for delivering drugs to the brain. Nanoparticles are being developed with increased efficiency and accuracy for overcoming the BBB and delivering neurospecific drugs to the brain. The zebrafish stands as an excellent model system to assess nanoparticle biocompatibility and toxicity. Hence, the zebrafish model is indispensable for the discovery or development of novel technologies for neurospecific drug delivery and potential therapies for brain diseases.

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“…1,2 Since 1500 BC, using the pills as a form of administration of drugs had the precedence. 3 Pill administration concept involves swallowing the pill and dissolving it in the stomach which is absorbed in the intestines and goes into circulation. Some limitations have been encountered in this approach, in cases of drugs which can break down in the stomach such as insulin.…”

Section: Introductionmentioning

confidence: 99%

“…10 The watershed in the drug delivery occurred in 1976 when Robert Langer and Judah Folkman discovered the large molecules could be delivered over days and weeks from polymer matrices. 3 The development was the replacement of waxy coatings with reproducible synthetic and more stable polymers that get gradually dissolved 7,11 to insure the sustained level of effective drug concentration in the blood and enhance the control on drug release with obviously efficient new DDSs. 12,13…”

Section: Introductionmentioning

confidence: 99%