Drug controlled releasing system based on polypyrrole modified multi-responsive hydrogel constructed from methacrylic acid and N-isopropylacrylamide

Peng, Shaohua; Liu, Hui

doi:10.1016/j.colsurfa.2023.131514

Cited by 5 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Obviously, all the n values are less than 0.5, suggesting that the releasing mechanism of FUDR from drugloaded PSOD vesicles under these environmental conditions belongs to typical Fick diffusion. [28] Study on cytotoxicity of PSOD Cell viability and cell imaging are employed to assess the cytotoxicity of PSOD, and the results are demonstrated in Figure 13. As can be observed from Figure 13(a), the cell viability can still remain above 90 % even after the culturing for 24 h with PSOD micelles, and moreover, the survival rate does not decrease with the increasing micelle concentration.…”

Section: Study On Drug Release Kinetics Of Ternary Random Copolymer Psodmentioning

confidence: 99%

Synthesis, Self‐Assembly and Drug Controlled Releasing Performance of Triple Responsive Ternary Copolymer Micelles

Peng,

Li,

Cai

et al. 2024

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

In order to avoid structural instability caused by the hydrolysis of spiropyran unit during responsive process, a new spiropyran monomer named as SPA was prepared by grafting carbamate functional groups to side chain of spiropyran frame. With SPA, 2‐(2‐(2‐methoxyethoxy) ethoxy) ethyl methacrylate (MEO3MA) and 2‐(diethylamino) ethyl methacrylate (DEAEMA) as the organic monomers, a triple responsive copolymer, P(SPA‐co‐MEO3MA‐co‐DEAEMA) abbreviated as PSOD, was obtained by one‐pot random copolymerization. The chemical structure, responsive behaviors and self‐assembly of the resulting copolymer were studied by a series of technical methods. With 5‐Fluoro‐2′‐deoxyuridin (FUDR) as the model anti‐cancer drug, the loading and controlled releasing behaviors of the copolymer micelles were systematically explored. Also, the cytotoxicity test and fluorescence imaging of PSOD copolymer were performed with human breast cancer cell line (MCF‐7) as the experimental subject. The results showed that the copolymer micelles had controllable drug releasing performance in complex combined stimuli conditions, and the releasing process could be well described by Korsmeyer‐Peppas model. The cytotoxicity of PSOD was proved to be relatively low, which laid a foundation for the subsequent in‐vivo drug releasing. Triple responsive performance of the copolymer micelles might provide a new inspiration for the future study of drug‐controlled releasing system.

show abstract

Section: Study On Drug Release Kinetics Of Ternary Random Copolymer Psodmentioning

confidence: 99%