Drug compliance and the Morisky Adherence Scale: An expression of concern and a warning

Li-Wan-Po, Alain; Peterson, Gregory M.

doi:10.1111/jcpt.13325

Cited by 6 publications

(6 citation statements)

References 17 publications

(22 reference statements)

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“…Therefore, even if one study represented each of these tools versus nine studies for MMAS‐8, this gave hope in regards to implementing them more in the clinical field. Hence, this might trigger future researchers to focus on testing them further, as they could be a safe free replacement to a previously well‐studied and frequently used scale 97 …”

Section: Discussionmentioning

confidence: 99%

Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Al‐Alaili

Abdi

Başgut

2022

Clinical Pharmacy Therapeu

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What Is Known and Objectives: Adherence has proved to have a positive influence on achieving plausible treatment outcomes. Self-report questionnaires are widely used in evaluating adherence, creating thus a high-powered research field. This review aims to provide an update of scales used in hypertension, which are compared and analysed against reliability and validity.Methods: PubMed, Web of Science and Cochrane Library were searched in May 2022 to identify studies. We extracted the study characteristics and evaluated their quality. A random-effects model with subgroup analysis was used to calculate estimates and heterogeneity parameters as well as regressions, funnel and forest plots. A bivariate model was selected to conduct validity analyses and draw receiver operating characteristic (ROC) curves.Results and Discussion: Fifty-five articles were identified and classified into 22 different reliable and validated tools. Pooled analyses predicted an overall good Cronbach's alpha of 0.76 (95%CI:0.67-0.83), a good ICC of 0.8 (95%CI:0.72-0.86) and an excellent correlation coefficient of 0.91 (95%CI:0.86-0.95), which all showed high heterogeneity and slight detection of asymmetry. Regression analyses showed that only

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Section: Discussionmentioning

confidence: 99%

Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Al‐Alaili

Abdi

Başgut

2022

Clinical Pharmacy Therapeu

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“…The higher the score, the better the medication compliance. Complete compliance: 8 points; partial compliance: 6–7 points; and non-compliance: <6 points ( 14 ). Total compliance rate = cases of (complete compliance + partial compliance)/total number of cases × 100%.…”

Section: Methodsmentioning

confidence: 99%

“…<6 points (14). Total compliance rate = cases of (complete compliance + partial compliance)/total number of cases × 100%.…”

Section: Medication Compliancementioning

confidence: 99%

Application Value of Information-Based Health Education and Continuity of Care in Patients With Peptic Ulcer

Liu

Yu-hua

Huang

et al. 2021

Front. Public Health

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Objective: This study is to assess the application value of information-based health education and continuity of care in patients with PU (peptic ulcer).Methods: Patients (116) with PU who have been treated in the hospital between January 2019 and October 2020 were taken as research objects and equally assigned to a control group and an observation group in a random manner. In contrast to the routine care applied to the control group, the observation group received information-based health education and continuity of care intervention. The clinical efficacy, the mastery of health knowledge, self-care ability, medication compliance, quality of life, mental state, and nursing satisfaction of the two groups were compared.Results: After the intervention, the total effective rate, health knowledge adequate rate, Exercise of Self-Care Agency (ESCA) scores of all dimensions, the MOS 36-item short-form health survey (SF-36) scores of all dimensions, medication compliance rate, and total nursing satisfaction of the observation group all notably exceeded those of the control group, with a p < 0.05. Patients of the group with continuity of care intervention showed lower Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores, as compared to the group with conventional care (p < 0.05).Conclusion: Information-based health education and continuity of care elevates the medication adherence and nursing satisfaction of patients with PU, enhances disease-related knowledge of patients and their self-care ability, and eventually ameliorates the quality of life and psychological state. It is worthy of clinical application.

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“…The term FIASMA (Functional Inhibitor of Acid SphingoMyelinAse) encompasses a family of drugs, many of them approved for use in humans, which have been shown to indirectly inhibit the activity of aSMase [ 100 ]. Interestingly, recent studies have shown that inhibition of lysosomal SMase via these inhibitors prevents infection of the SARS-CoV-2 virus [ 101 , 102 , 103 ]. In Niemann–Pick disease, it has been observed that aSMase dysfunction leads to a dysregulation of lysosomes, causing a disruption of cholesterol transport [ 104 ].…”

Section: Enzymes Of Ceramide Metabolismmentioning

confidence: 99%

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

et al. 2021

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Sphingolipids are both structural molecules that are essential for cell architecture and second messengers that are involved in numerous cell functions. Ceramide is the central hub of sphingolipid metabolism. In addition to being the precursor of complex sphingolipids, ceramides induce cell cycle arrest and promote cell death and inflammation. At least some of the enzymes involved in the regulation of sphingolipid metabolism are altered in carcinogenesis, and some are targets for anticancer drugs. A number of scientific reports have shown how alterations in sphingolipid pools can affect cell proliferation, survival and migration. Determination of sphingolipid levels and the regulation of the enzymes that are implicated in their metabolism is a key factor for developing novel therapeutic strategies or improving conventional therapies. The present review highlights the importance of bioactive sphingolipids and their regulatory enzymes as targets for therapeutic interventions with especial emphasis in carcinogenesis and cancer dissemination.

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Drug compliance and the Morisky Adherence Scale: An expression of concern and a warning

Cited by 6 publications

References 17 publications

Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Test performance of self‐report adherence tools in patients with hypertension: A systematic review and a meta‐analysis

Application Value of Information-Based Health Education and Continuity of Care in Patients With Peptic Ulcer

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

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