Drug combinations screening using a Bayesian ranking approach based on dose–response models
Luana Boumendil,
Morgane Fontaine,
Vincent Lévy
et al.
Abstract:Drug combinations have been of increasing interest in recent years for the treatment of complex diseases such as cancer, as they could reduce the risk of drug resistance. Moreover, in oncology, combining drugs may allow tackling tumor heterogeneity. Identifying potent combinations can be an arduous task since exploring the full dose–response matrix of candidate combinations over a large number of drugs is costly and sometimes unfeasible, as the quantity of available biological material is limited and may vary … Show more
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