Drug‐coated balloons for the treatment of in‐stent restenosis in diabetic patients: A review of currently available scientific data

Minacapelli, Alberto; Piraino, Davide; Buccheri, Dario; Cortese, Bernardo

doi:10.1002/ccd.26957

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…is proposed phenomenon was corresponding to the underling mechanism of restenosis of the coronary arteries [39,40]. Further basic researches are required to validate the above hypothesis.…”

Section: 2mentioning

confidence: 83%

Effect of Lifestyle Changes after Percutaneous Coronary Intervention on Revascularization

Wang

Xian

Chen

et al. 2020

BioMed Research International

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Objective. Whether optimal cardiovascular health metrics may reduce the risk of cardiovascular events in secondary prevention is uncertain. The study was conducted to evaluate the influence of lifestyle changes on clinical outcomes among the subjects underwent percutaneous coronary intervention (PCI). Methods. The study group consists of 17,099 consecutive PCI patients. We recorded data on subject lifestyle behavior changes after their procedure. Patients were categorized as ideal, intermediate, or poor CV health according to a modified Life’s Simple 7 score (on body mass, smoking, physical activity, diet, cholesterol, blood pressure, and glucose). Multivariable COX regression was used to evaluate the association between CV health and revascularization event. We also tested the impact of cumulative cardiovascular health score on reoccurrence of cardiovascular event. Results. During a 3-year median follow-up, 1,583 revascularization events were identified. The observed revascularization rate was 8.0%, 9.3%, and 10.6% in the group of patients with optimal (a modified Life’s Simple 7 score of 11–14), average (score = 9 or 10), or inadequate (less or equal than 8) CV health, respectively. After multivariable analysis, the adjusted hazard ratios were 0.83 (95% CI: 0.73–0.94) and 0.89 (95% CI: 0.79–0.99) for patients with optimal and average lifestyle changes comparing with the inadequate tertile (P for trend = 0.003). In addition, each unit increase in above metrics was associated with a decrease risk of revascularization (HR, 0.96; 95% confidence interval, 0.93–0.98; P<0.001). Conclusion. Ideal CV health related to lower incidence of cardiovascular events, even after the percutaneous coronary intervention. Revascularization can be reduced by lifestyle changes. The cardiovascular health metrics could be extrapolated to secondary prevention and need for further validation.

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“…is proposed phenomenon was corresponding to the underling mechanism of restenosis of the coronary arteries [39,40]. Further basic researches are required to validate the above hypothesis.…”

Section: 2mentioning

confidence: 83%

Effect of Lifestyle Changes after Percutaneous Coronary Intervention on Revascularization

Wang

Xian

Chen

et al. 2020

BioMed Research International

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“…In-stent restenosis is widely acknowledged as a major complication after PCI. Even though using DES decreases the incidence of ISR from 30 to 5% compared with BMS, the incidence remains high for patients with inflammation or other comorbidities such as diabetes (19,20). Indeed, DCB was originally developed to prevent ISR (16).…”

Section: Application Of Dcb In In-stent Restenosismentioning

confidence: 99%

Novel application of drug-coated balloons in coronary heart disease: A narrative review

Wang

Li²,

Li³

et al. 2023

Front. Cardiovasc. Med.

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The incidence of coronary heart disease (CAD) has soared over the years, and coronary intervention has become an increasingly important therapeutic approach. The past decade has witnessed unprecedented developments in therapeutic medical instruments. Given that drug-coated balloons bring many benefits, they are indicated for an increasing number of conditions. In this article, we review the results of current clinical trials about drug-coated balloons and summarize their safety and clinical progression in different coronary artery diseases, laying the groundwork for basic research, and clinical therapeutics of this patient population.

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“…Drug-coated balloon angioplasty is similar to plain old balloon angioplasty, with the addition of an antiproliferative medication coating on the balloon, which helps reduce and prevent restenosis [ 26 – 28 ]. The drug coating comprises an active drug and a carrier.…”

Section: Evidence-based Practice Of Treating Isr Using Dcbsmentioning

confidence: 99%

In-Stent Restenosis and a Drug-Coated Balloon: Insights from a Clinical Therapeutic Strategy on Coronary Artery Diseases

Zhang

Chen

2020

Cardiology Research and Practice

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Coronary heart disease is a major cause of death and disability in developed countries. Stent implantation has become an efficacious treatment for a culprit lesion vessel of the coronary artery. However, 10%–20% restenosis is still an important complication that restricts the clinical safety and efficacy of drug-eluting stents. In-stent restenosis may lead to the recurrence of major cardiovascular adverse events, including angina pectoris, acute myocardial infarction, and even sudden cardiac death. These events are currently serious problems that occur after coronary stent implantation. Clinical physicians face a difficult choice for in-stent restenosis treatment. Recent studies indicate that a drug-coated balloon has promising clinical efficacy similar to the drug-eluting stents for treating coronary in-stent restenosis. Therefore, in this study, we highlight the progress of coronary intervention and the use of drug-coated balloons in the treatment of in-stent restenosis (ISR).

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Drug‐coated balloons for the treatment of in‐stent restenosis in diabetic patients: A review of currently available scientific data

Cited by 6 publications

References 54 publications

Effect of Lifestyle Changes after Percutaneous Coronary Intervention on Revascularization

Effect of Lifestyle Changes after Percutaneous Coronary Intervention on Revascularization

Novel application of drug-coated balloons in coronary heart disease: A narrative review

In-Stent Restenosis and a Drug-Coated Balloon: Insights from a Clinical Therapeutic Strategy on Coronary Artery Diseases

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