Drug catalyzed polymerization yields one pot nanomedicines

Hurst, Paul Joshua; Gassaway, Kyle J.; Abouchaleh, Mohammed Faris; Idris, Nehal S.; Jones, Chelsea R.; Dicksion, Chris A.; Nowick, James S.; Patterson, Joseph P.

doi:10.1039/d3lp00135k

RSC Appl. Polym.

2024

DOI: 10.1039/d3lp00135k

|View full text |Cite

Drug catalyzed polymerization yields one pot nanomedicines

Paul Joshua Hurst,

Kyle J. Gassaway,

Mohammed Faris Abouchaleh

et al.

Abstract: In this work, by using drugs as a catalyst coupled with a polymerization-induced self-assembly process, we synthesise drug-polymer particles in one pot compared to a standard stepwise process.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods

Hurst,

Yoon,

Singh

et al. 2024

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

Polymerization‐induced self‐assembly (PISA) has emerged as a scalable one‐pot technique to prepare block copolymer nanoparticles. Recently, we developed a PISA process that resulted in poly(L‐lactide)‐b‐poly(ethylene glycol) block copolymer nanoparticles coined ring‐opening polymerization‐induced crystallization‐driven self‐assembly (ROPI‐CDSA). The resulting nanorods demonstrated a strong propensity for aggregation, resulting in the formation of 2D sheets and 3D networks. Here, we report the synthesis of poly(N,N‐dimethyl acrylamide)‐b‐poly(L)‐lactide block copolymer nanoparticles by ROPI‐CDSA utilizing a two‐step, one‐pot approach. A dual‐functionalized photoiniferter was first used for controlled radical polymerization of the acrylamido‐based monomer, and the resulting polymer served as a macroinitiator for organocatalyzed ring‐opening polymerization to form the solvophobic polyester block. The resulting nanorods are highly stable and display anisotropy at higher molecular weights (>12k Da) and concentrations (>20% solids) than our previous report. This development expands the chemical scope of ROPI‐CDSA block copolymers and provides readily accessible nanorods made with biocompatible materials.This article is protected by copyright. All rights reserved

show abstract

Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods

Hurst,

Yoon,

Singh

et al. 2024

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Drug catalyzed polymerization yields one pot nanomedicines

Abstract: In this work, by using drugs as a catalyst coupled with a polymerization-induced self-assembly process, we synthesise drug-polymer particles in one pot compared to a standard stepwise process.

Cited by 1 publication

References 62 publications

Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods

Hybrid Photoiniferter and Ring‐Opening Polymerization Yields One‐Pot Anisotropic Nanorods

Contact Info

Product

Resources

About