Drug-Carrying Magnetic Nanocomposite Particles for Potential Drug Delivery Systems

Abstract

Recommended by Sakhrat KhizroevDrug-carrying magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-coglycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼13 nm on average) of magnetite were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5-2 hours agitation for the synthesis of nanocomposite spheres. Specifically, PLGA and drug were first dissolved in acetonitrile (oily phase I) and combined with magnetic nanoparticles, then added dropwise into viscous paraffin oil combined with Span 80 (oily phase II). With different contents (0%, 10%, 20%, and 25%) of magnetite, the nanocomposite spheres were evaluated in terms of particle size, morphology, and magnetic properties by using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and a superconducting quantum interference device (SQUID). The results indicate that nanocomposite spheres (200 nm to 1.1 μm in diameter) are superparamagnetic above the blocking temperature near 40 K and their magnetization saturates above 5 000 Oe at room temperature.

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“…Characterization of nanobiocomposite involves techniques such as Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), differential scanning colorimetry (DSC), thermogravimetric analysis (TGA), differential thermal analysis, superconducting quantum interference device (SQUID), nuclear magnetic resonance, and X-ray diffraction (XRD). [16,[19][20][21][22][23] Nanobiocomposite hydrogel is prepared by addition of nanoclay, which results in increased in water retention in gel and provides a platform for hydrogel, which is used in drug delivery and contact lenses. [24] The combination of biopolymer and hydroxyapatite are mainly used in the lung drug delivery.…”

“…Oil phase is then emulsified in the aqueous phase with sonication for 120 s. The formed emulsion was allowed to evaporate overnight at room temperature to harden the particles. [22,34]…”

“…Ca-P nanoparticles were dispersed in the PHBV-chloroform solution using ultrasonication and homogenization to form a s/o nanosuspension and it is dispersed in the inner water phase (the aqueous BSA solution), followed by the same procedure for PHBV-BSA microsphere preparation. [22,41]…”

Physical energy for drug delivery; poration, concentration and activation

“…The enhancement of effective drug delivery to the target achieved by the addition of physical energy to the traditional TDDS systems has been widely explored in recent years [29–36]. These techniques have the potential to be used in different biological and medical applications as an advanced TDDS that can minimize the current limitations and unwanted effects.…”

Synthesis and characterization of targeted bar encapsulated polylactic-co-glycolic acid nanoparticles to inhibit porphyromonas gingivalis biofilm formation.

“…The initial burst of active agent during the release from nanoparticles is dependent on the drug and polymer hydrophobicity. In the second phase, the drug is gradually released as water hydrolyzes the polymer into oligomeric and monomeric products (43)(44).…”