Drug attitude as predictor for effectiveness in first-episode schizophrenia: Results of an open randomized trial (EUFEST)

Gäebel, Wolfgang; Riesbeck, Mathias; Wilmsdorff, Martina von; Burns, Tom; Derks, Eske M.; Kahn, René S.; Rössler, Wulf; Fleischhacker, W. Wolfgang

doi:10.1016/j.euroneuro.2010.02.001

Cited by 55 publications

(41 citation statements)

References 28 publications

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“…En la medida en que se mantenga una adecuada adherencia farmacológica se reducen las recaídas, se obtiene un mejor curso sintomatológico e incluso promueve una mejor interacción social. Cabe destacar que en la misma línea de estudios anteriores, [53][54][55][56][57] la severidad del trastorno presenta una asociación importante en la adherencia a la medicación. Si bien no se puede establecer causalidad, es posible que los pacientes más gravemente afectados presenten una menor adherencia, sin embargo, es posible también que al presentar menor adherencia se descontinúa el tratamiento y, por ende, el paciente recae (mayor severidad).…”

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Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

Caqueo-Urízar

Urzúa-M

Miranda‐Castillo

et al. 2016

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Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

Caqueo-Urízar

Urzúa-M

Miranda‐Castillo

et al. 2016

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“…In a study in the 1st episode of schizophrenia, DAI-30 cut off point was 20 in order to determine predictive validity (21). In another study DAI-10 scores in patients admitted to psychiatric ward were associated with understanding the need for medication but not with the daily use or the number of medications (22).…”

Section: Introductionmentioning

confidence: 99%

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Shariati

Shabani

Arianakia

et al. 2018

Iran J Psychiatry Behav Sci

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Background: A negative attitude toward treatment is a major obstacle to treat bipolar disorder. Objectives: The current study aimed at assessing the reliability and validity of Persian version of drug attitude inventory (DAI-10) in patients with bipolar I disorder and finding its relationship with patients' compliance in order to predict the disorder. Methods: To assess test-retest reliability, 30 outpatients with bipolar I disorder were selected. They were asked to answer the questions at the onset of the study and four to ten days later. Then, the relationship between DAI-10 scores of 82 patients in bipolar disorder patients' follow-up (BDPF) study, and medication possession ratio (MPR) were investigated. The patients were divided into poor and good compliance, and cut off point of the tool was assigned. Positive and negative predictive value of DAI score was also calculated.

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“…80 If insight and attitudes change, scores after response should be more predictive of relapse, readmission, and remission than initial attitudes, contrary to some previous data. 52,64,80 Both trait-like and state-driven aspects were evidenced in a stable, early psychosis group. 98 Self-esteem during acute initial psychosis is usually studied retrospectively.…”

Section: Modeling Drug Attitudes and Insight In Early Schizophreniamentioning

confidence: 99%

“…Attitudes to medication. These attitudes are consistently important predictors when assessed in early illness, 20,42,[63][64][65] even when potential proxies such as detention or initial medication refusal are included 14,66,67 : overall hostility predicts negative attitudes and poor early adherence. 53,66 Occasional studies find that attitudes are not predictive.…”

Section: Antipsychotic Formulation Long Acting Injectablementioning

confidence: 99%

Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention

Drake

Nordentoft

Haddock

et al. 2015

Schizophrenia Bulletin

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We aimed to design a multimodal intervention to improve adherence following first episode psychosis, consistent with current evidence. Existing literature identified medication attitudes, insight, and characteristics of support as important determinants of adherence to medication: we examined medication attitudes, self-esteem, and insight in an early psychosis cohort better to understand their relationships. Existing longitudinal data from 309 patients with early Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, nonaffective psychosis (83% first episode) were analyzed to test the hypothesis that medication attitudes, while meaningfully different from "insight," correlated with insight and self-esteem, and change in each influenced the others. Rosenberg SelfEsteem Scale, Birchwood Insight Scale, and Positive and Negative Syndrome Scale insight were assessed at presentation, after 6 weeks and 3 and 18 months. Drug Attitudes Inventory (DAI) and treatment satisfaction were rated from 6 weeks onward. Structural equation models of their relationships were compared. Insight measures' and DAI's predictive validity were compared against relapse, readmission, and remission. Analysis found five latent constructs best fitted the data: medication attitudes, selfesteem, accepting need for treatment, self-rated insight, and objective insight. All were related and each affected the others as it changed, except self-esteem and medication attitudes. Low self-reported insight at presentation predicted readmission. Good 6-week insight (unlike drug attitudes) predicted remission. Literature review and data modeling indicated that a multimodal intervention using motivational interviewing, online psychoeducation, and SMS text medication reminders to enhance adherence without damaging self-concept was feasible and appropriate.

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Drug attitude as predictor for effectiveness in first-episode schizophrenia: Results of an open randomized trial (EUFEST)

Cited by 55 publications

References 28 publications

Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

Adherencia a la medicación antipsicótica en pacientes indígenas con esquizofrenia

Drug Attitude Inventory In Bipolar I Patients: Psychometric Properties

Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention

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