Drug-Associated Liver Injury Related to Antipsychotics

Zeiss, René; Hafner, Susanne; Schönfeldt‐Lecuona, Carlos; Connemann, Bernhard J.; Gahr, Maximilian

doi:10.1097/jcp.0000000000001576

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…Based on the highest possible plasma or serum drug concentrations, the concentrations were chosen ( 30–38 ). In a prior investigation, the liver toxicity of these medications was documented and reviewed ( 39 ). Therefore, using HepaRG cells to carry out a cell viability assay, we evaluated the toxicity of these APs.…”

Section: Resultsmentioning

confidence: 99%

Influence of antipsychotic medications on hyperlipidemia risk in patients with schizophrenia: evidence from a population-based cohort study and in vitro hepatic lipid homeostasis gene expression

Tien

Lin

et al. 2023

Front. Med.

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IntroductionSchizophrenia increases the risk of mortality and cardiovascular disease (CVD) risk. However, the correlation between antipsychotics (APs) and CVD remains controversial. Hyperlipidemia is a significant risk factor for CVD.MethodsWe conducted a nationwide population-based retrospective cohort study to investigate the effects of APs on the risk of hyperlipidemia and lipid homeostasis gene expression. We used data from the Longitudinal Health Insurance Database of Taiwan on new-onset schizophrenia patients and a comparison cohort without schizophrenia. We used a Cox proportional hazards regression model to analyze the differences in hyperlipidemia development between the two cohorts. Furthermore, we examined the effects of APs on the hepatic expression of lipid homeostasis-related genes.ResultsAfter adjusting for potential interrelated confounding factors, the case group (N = 4,533) was found to have a higher hyperlipidemia risk than the control cohort (N = 4,533) [adjusted hazard ratio (aHR), 1.30, p < 0.001]. Patients with schizophrenia without APs had a significantly higher risk of hyperlipidemia (aHR, 2.16; p < 0.001). However, patients receiving APs had a significantly lower risk of hyperlipidemia than patients not receiving APs (all aHR ≤ 0.42, p < 0.001). First-generation antipsychotics (FGAs) induce the expression of hepatic lipid catabolism genes in an in vitro model.DiscussionPatients with schizophrenia had a higher risk of hyperlipidemia than controls; however, compared with non-treated patients, AP users had a lower risk of hyperlipidemia. Early diagnosis and management of hyperlipidemia may help prevent CVD.

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Section: Resultsmentioning

confidence: 99%

Influence of antipsychotic medications on hyperlipidemia risk in patients with schizophrenia: evidence from a population-based cohort study and in vitro hepatic lipid homeostasis gene expression

Tien

Lin

et al. 2023

Front. Med.

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“…The datasets analyzed for deducing statistical patterns and different graphical representations were also plotted for visual analysis of data. 37 - 43 …”

Section: Introductionmentioning

confidence: 99%

Exploratory data analysis of physicochemical parameters of natural antimicrobial and anticancer peptides: Unraveling the patterns and trends for the rational design of novel peptides

Saini¹,

Rathore²,

Sharma³

et al. 2023

Bioimpacts

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Introduction: Peptide-based research has attained new avenues in the antibiotics and cancer drug resistance era. The basis of peptide design research lies in playing with or altering physicochemical parameters. Here in this work, we have done exploratory data analysis (EDA) of physicochemical parameters of antimicrobial (AMPs) and anticancer (ACPs) peptides, two promising therapeutics for microbial and cancer drug resistance to deduce patterns and trends. Methods: Briefly, we have captured the natural AMPs and ACPs data from the APD3 database. After cleaning the data manually and by CD-HIT web server, further data analysis has been done using Python-based packages, modlAMP and Pandas. We have extracted the descriptive statistics of 10 physicochemical parameters of AMPs and ACPs to build a comprehensive dataset containing all major parameters. The global analysis of datasets has been done using modlAMP to find the initial patterns in global data. The subsets of AMPs and ACPs were curated based on the length of the peptides and were analyzed by Pandas package to deduce the graphical profile of AMPs and ACPs. Results: EDA of AMPs and ACPs shows selectivity in the length and amino acid compositions. The distribution of physicochemical parameters in defined quartile ranges was observed in the descriptive statistical and graphical analysis. The preferred length range of AMPs and ACPs was found to be 21-30 amino acids, whereas few outliers in each parameter were evident after EDA analysis. Conclusion: The derived patterns from natural AMPs and ACPs can be used for the rational design of novel peptides. The statistical and graphical data distribution findings will help in combining the different parameters for potent design of novel AMPs and ACPs.

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“…We thank Dr Raschi and colleagues for their instructive comments 1 on our study 2 and valuable suggestions for future research. First of all, we would like to thank the authors for recognizing the clinical relevance of drug-induced liver injury (DILI) and our work.…”

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confidence: 98%

Response to the Letter to the Editors by Raschi et al: “Antipsychotics and Drug-Associated Liver Injury: Toward Minimum Requirements in Reporting Pharmacovigilance Studies”

Zeiss

Gahr

2023

J Clin Psychopharmacol

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Drug-Associated Liver Injury Related to Antipsychotics

Cited by 9 publications

References 48 publications

Influence of antipsychotic medications on hyperlipidemia risk in patients with schizophrenia: evidence from a population-based cohort study and in vitro hepatic lipid homeostasis gene expression

Influence of antipsychotic medications on hyperlipidemia risk in patients with schizophrenia: evidence from a population-based cohort study and in vitro hepatic lipid homeostasis gene expression

Exploratory data analysis of physicochemical parameters of natural antimicrobial and anticancer peptides: Unraveling the patterns and trends for the rational design of novel peptides

Response to the Letter to the Editors by Raschi et al: “Antipsychotics and Drug-Associated Liver Injury: Toward Minimum Requirements in Reporting Pharmacovigilance Studies”

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