Drug and excipient diffusion and solubility in acrylate adhesives measured by infrared-attenuated total reflectance (IR-ATR) spectroscopy

Cantor, Adam S.

doi:10.1016/s0168-3659(99)00119-4

Cited by 13 publications

(5 citation statements)

References 10 publications

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“…Already published data by Cantor (1999) and Roy et al (1996) were in the same order of magnitude (Table 1). The diffusion coefficient in the silicone adhesive BIO-PSA 7-4202 of Paeonol was the highest followed by the diffusion coefficient in the acrylic adhesive.…”

Section: Discussionsupporting

confidence: 56%

“…When measuring a low drug release rate during penetration tests it is not known, whether this is due to adhesive retarding effects or due to a low diffusity of the drug in the skin (Cantor, 1999). Cantor (1999) measured the diffusion coefficients of several compounds in different acrylic adhesives.…”

Section: Introductionmentioning

confidence: 99%

“…Cantor (1999) measured the diffusion coefficients of several compounds in different acrylic adhesives. Here, the diffusion coefficient of the drugs in the adhesives served as indicator for the later release properties on skin.…”

Section: Introductionmentioning

confidence: 99%

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Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems

et al. 2014

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Release from a transdermal drug delivery system (TDDS) can either be controlled by diffusion in the adhesive, by diffusion processes in the stratum corneum of the skin or a combination of both. In this study, diffusion processes in monolithic type TDDS were investigated using confocal Raman microscopy. An acrylic adhesive (Duro-Tak 180-129a), a rubber adhesive (Duro-Tak H1540) and a silicone adhesive (BIO-PSA 7-4202) were used. Skin permeation of the model drug Paeonol from these adhesives was investigated. Release studies on porcine cadaver skin were carried out. Solubility of Paeonol in the different adhesives was measured. Diffusion coefficients of the drug in the TDDSs were calculated from confocal Raman depth scans, the diffusion coefficient in the stratum corneum was calculated using tape stripping. Solubility of Paeonol in the acrylic adhesive was the highest with 30 g/L among the tested systems. Paeonol had a solubility of 6 and 9 g/L in the silicone and rubber based system. Diffusion coefficient rank order was BIO-PSA 7-42044Duro-Tak 180-129a4Duro-Tak H1540. Release on porcine cadaver skin from the silicone was the highest followed by the rubber and the acrylic adhesive. During release studies on porcine skin with Duro-Tak H1540 no concentration gradient of Paeonol could be monitored in the Raman depth profiles, whereas in the stratum corneum an apparent diffusion gradient was detectable. Solubility of a drug in the adhesive dominated the release properties, high-diffusion coefficients of drugs in adhesives do not necessarily lead to high release rates from adhesives.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems

et al. 2014

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“…Infra red attenuated total reflectance (IR-ATR) spectroscopy can determine solubility in acrylate adhesives [10,11]. The colorimetric determination of betamethasone in a topical vehicle by oxidation and then condensation of the 17 ␣-ketol group with phenylhydrazine has also been successfully demonstrated [12].…”

Section: Introductionmentioning

confidence: 99%

Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques

Ahmed

Barry

Williams

et al. 2004

Journal of Pharmaceutical and Biomedical Analysis

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“…Attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy is a molecular spectroscopic technique with unique surface-sensitive properties derived from the rapid decay of the strong evanescent field generated under the total internal reflection (TIR) phenomenon. [1][2][3][4][5] Although the rapid decay characteristic of the evanescent field makes the ATR spectrum sensitive to physicochemical phenomena near the interface, restrictions associated with the decay characteristic impose limitations on the application of the technique. The sample must optically contact the internal reflection element (IRE) in order to exploit the strong evanescent field near the interface.…”

Section: Introductionmentioning

confidence: 99%

Novel Attenuated Total Reflection Fourier Transform Infrared Microscopy Using a Gem Quality Diamond as an Internal Reflection Element

Ekgasit

Thongnopkun

2005

Appl Spectrosc

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A novel technique for attenuated total reflection Fourier transform infrared (ATR FT-IR) spectral acquisition by an infrared microscope with a gem-quality faceted diamond as an internal reflection element (IRE) is introduced. Unlike conventional IREs, the novel diamond IRE has a sharp tip configuration instead of a flat tip configuration. Light at normal incidence was coupled into the diamond while the transflected radiation from the diamond was collected through the table facet by the built-in 15x Cassegrainian objective. The number of reflections in the novel diamond IRE equals two. The evanescent field generated under total internal reflection at the pavilion facet was exploited for ATR spectral acquisition of materials attached to the IRE. The observed ATR spectra were compared to those obtained via a traditional zinc selenide IRE.

show abstract

Drug and excipient diffusion and solubility in acrylate adhesives measured by infrared-attenuated total reflectance (IR-ATR) spectroscopy

Cited by 13 publications

References 10 publications

Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems

Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems

Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques

Novel Attenuated Total Reflection Fourier Transform Infrared Microscopy Using a Gem Quality Diamond as an Internal Reflection Element

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