Drug and Environmental Factors Associated with Adverse Pregnancy Outcomes Part I: Antiepileptic Drugs, Contraceptives, Smoking, and Folate

Lewis, D P; Dyke, Don C. Van; Stumbo, Phyllis J.; Berg, Mary

doi:10.1345/aph.17297

Cited by 49 publications

(41 citation statements)

References 151 publications

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“…Folic acid deficiency has been postulated as a possible cofactor in the teratogenic effects associated with the maternal use of AEDs during pregnancy [13,18,31,33].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

et al. 2008

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“…Folic acid deficiency has been postulated as a possible cofactor in the teratogenic effects associated with the maternal use of AEDs during pregnancy [13,18,31,33].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

et al. 2008

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“…Folate deficiency has long been recognized as an important contributor to susceptibility for birth defects (Lewis et al, 1998;Lucock, 2000) and epidemiological studies have demonstrated a beneficial effect of folate supplementation on prevention of birth defects (Berry and Li, 2002;Czeizel et al, 1999;Molloy and Scott, 2001;Ray et al, 2002). These studies have focused on neural tube defects and craniofacial abnormalities, due to their ease of detection at birth and visual ascertainment criteria (Berry and Li, 2002).…”

Section: Introductionmentioning

confidence: 99%

Folate modulates Hox gene‐controlled skeletal phenotypes

Kappen

Mello

Finnell

2004

Genesis

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Hox genes are well known regulators of pattern formation (Capecchi, 1996;Krumlauf, 1994) and cell differentiation (Goff and Tabin, 1997;Papenbrock et al., 2000;Yueh et al., 1998) in the developing vertebrate skeleton. Although skeletal variations are not uncommon in humans (Hald et al., 1995), few mutations in human HOX genes have been described (Goodman and Scambler, 2001). If such mutations are compatible with life, there may be physiological modifiers for the manifestation of Hox gene-controlled phenotypes, masking underlying mutations. We here present evidence that the essential nutrient folate modulates genetically induced skeletal defects in Hoxd4 transgenic mice. We also show that chondrocytes require folate for growth and differentiation and that they express folate transport genes, providing evidence for a direct effect of folate on skeletal cells. To our knowledge, this is the first report of nutritional influence on Hox gene controlled phenotypes, and implicates gene-environment interactions as important modifiers of Hox gene function. Taken together, our results demonstrate a beneficial effect of folate on skeletal development that may also be relevant to disorders and variations of the human skeleton.

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“…These associations are consanguinity with monogenic disorders, high maternal age with chromosomal anomalies [12, 13], low maternal age with gastroschisis [16, 17], antiepileptics (valproic acid) with neural tube defects [14, 15, 18]and diabetes with cardiovascular defects [19, 20]. …”

Section: Discussionmentioning

confidence: 99%

Birth Defect and Risk Factor Surveillance in the Northern and Southwestern Netherlands

Reefhuis

Zandwijken²,

Walle³

et al. 1999

Public Health Genomics

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Objective: To survey the associations between several risk factors and birth defects, in order to detect potential new teratogens. Methods: Data of the two Dutch European Registration of Congenital Anomalies (EUROCAT) registries collected before January 1, 1998 were used to perform χ² tests for a large number of risk factors and birth defects. Defects caused by chromosomal or monogenic disorders were analyzed separately. Results: Cross-tabulations of 80 groups of birth defects with 303 risk factors were studied. Of these, 126 combinations had a p value under 0.05, and 34 had a p value under 0.001. Of these 34 associations, some are known in the literature, some were found before in the same databases and some were new associations. Conclusions: This is a good method for generating new hypotheses for associations between risk factors and birth defects. It can be a start for new, more in-depth studies of potential teratogens.

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Drug and Environmental Factors Associated with Adverse Pregnancy Outcomes Part I: Antiepileptic Drugs, Contraceptives, Smoking, and Folate

Cited by 49 publications

References 151 publications

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy

Folate modulates Hox gene‐controlled skeletal phenotypes

Birth Defect and Risk Factor Surveillance in the Northern and Southwestern Netherlands

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