Drug and chemical induced photosensitivity from a clinical perspective

Ibbotson, S.H.

doi:10.1039/c8pp00011e

Cited by 33 publications

(63 citation statements)

References 205 publications

(259 reference statements)

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“…In specialized photodiagnostic units, systemic drug‐induced photosensitivity is reported to account for up to 15% of photodermatoses . However, these cases only represent those actually referred for investigation of suspected photosensitivity and as such do not reflect the true incidence …”

Section: Discussionmentioning

confidence: 99%

“…As a result, physicians without a particular interest in photodermatology may only occasionally see and report cases of druginduced photosensitivity. 10 Due to underreporting as well as the diversity and abundance of drugs with photosensitizing potential, there are only rough approximations as to the actual incidence of photosensitive reactions. In a report by Chaabane et al 19 on patients presenting with drug-induced skin adverse reactions, photosensitivity was the third commonest cause.…”

Section: Discussionmentioning

confidence: 99%

“…[20][21][22][23][24][25] However, these cases only represent those actually referred for investigation of suspected photosensitivity and as such do not reflect the true incidence. 10 Up to the present, a large quantity of drugs has been associated with photosensitivity and this number is increasing constantly. 8 As part of our analysis, we have identified 387 drugs with photosensitivity reported in the literature or in drug databases.…”

Section: Discussionmentioning

confidence: 99%

“…In general, the elderly population is at higher risk given its greater consumption of different drugs for the treatment of chronic diseases . Besides acute cutaneous adverse effects, an increasing number of reports also suggest chronic sequelae such as increased photoaging or photocarcinogenesis . However, as yet this is still a matter of controversial scientific discussions.…”

Section: Introductionmentioning

confidence: 99%

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The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature

Hofmann

Gradl²,

Schulz

et al. 2019

Acad Dermatol Venereol

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Background Drug‐induced photosensitivity refers to the development of cutaneous adverse events due to interaction between a pharmaceutical compound and sunlight. Although photosensitivity is a very commonly listed side‐effect of systemic drugs, reliable data on its actual incidence are lacking so far. Objectives A possible approach to evaluate the real‐life extent of drug‐induced photosensitivity would be an analysis of the frequency of exposure to a given photosensitizing drug combined with an indicator of its photosensitizing potential. This could serve as a basis for developing a pharmaceutical ‘heatmap’ of photosensitivity. Methods The present study investigated the number of reimbursed dispensed packages of potentially photosensitizing drugs in Germany (DE) and Austria (AT) between 2010 and 2017 based on nationwide health insurance‐based databases. In addition, an indicator for the photosensitizing potential was established for each drug based on the number of reports on photosensitivity in the literature. Results This analysis includes means of 632 826 944 (+/−14 894 918) drug dispensings per year in DE and 113 270 754 (+/−1 964 690) in AT. Out of these, the mean percentage of drugs that enlist photosensitivity as a potential side‐effect was 49.5% (±0.7) in DE and 48.2% (±1.2) in AT. When plotting the number of reimbursed dispensed packages vs. the number of reports on photosensitivity, two categories of drugs show high numbers for both parameters, that is diuretics and non‐steroidal anti‐inflammatory drugs (NSAIDs). Conclusions Diuretics and NSAIDs appear to be responsible for the greatest part of exposure to photosensitizing drugs with potential implication on public health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature

Hofmann

Gradl²,

Schulz

et al. 2019

Acad Dermatol Venereol

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“…4,5 Phototoxicity may theoretically occur in any individual exposed to enough of the drug or relevant wavelength of UVR, although the threshold differs across individuals. 4 Photoallergic reactions to systemic drugs are less common, more often occurring due to topical agents. They are mediated by cell-mediated type IV hypersensitivity responses and require sensitization to the offending drug.…”

Section: Introductionmentioning

confidence: 99%

Systemic drug photosensitivity—Culprits, impact and investigation in 122 patients

Alrashidi

Rhodes

Sharif

et al. 2020

Photoderm Photoimm Photomed

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Background: Systemic drugs are a potentially reversible cause of photosensitivity. We explore prevalence, impact, phototest findings and culprit drugs. Methods: Retrospective review of patients was diagnosed with drug-induced photosensitivity in a specialist photoinvestigation centre (2000-2016), using data recorded in standardized pro forma. Patients underwent detailed clinical evaluation. Monochromator phototesting was performed to 300 ± 5 nm, 320 ± 10 nm,

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Cutaneous Photosensitivity Diseases

Ibbotson

2024

Rook's Textbook of Dermatology

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The photodermatoses are a diverse group of conditions in which abnormal responses to light exposure are the hallmark. Photodiagnostic investigations through a specialist unit may be essential to ensure accurate diagnosis and management, and this chapter explores the nature of the photodermatoses and the photodiagnostic techniques that can be applied. Management approaches include early diagnosis, prevention and disease suppression, and awareness of the significant adverse impact on well‐being and psychological health that can occur with photosensitivity. Photoprotection is a mainstay approach for the photodermatoses but is often not sufficient alone for disease control. Desensitisation through natural hardening or light‐based therapies may be feasible, although systemic immunosuppressants and immunomodulators may be required. Awareness of the possibility of vitamin D deficiency is also necessary. This chapter will cover these approaches in detail.

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Drug and chemical induced photosensitivity from a clinical perspective

Abstract: Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved.

Cited by 33 publications

References 205 publications

The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature

The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature

Systemic drug photosensitivity—Culprits, impact and investigation in 122 patients

Cutaneous Photosensitivity Diseases

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