Drug allergy in university students from Porto, Portugal

Falcão, Helena; Lunet, Nuno; Gomes, Eva; Cunha, Liliana; Barros, Henrique

doi:10.1034/j.1398-9995.2003.00291.x

Cited by 15 publications

(16 citation statements)

References 3 publications

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“…To our knowledge, this is the first study in the literature concerning the prevalence of parental‐reported drug allergy in childhood. In our survey, it was lower than the prevalence previously reported for adults (11, 12). This may be due to lower drug consumption in children compared with adults or because some parents may not have considered the reactions to be allergic.…”

Section: Discussioncontrasting

confidence: 91%

“…β ‐Lactams, TMP–SMZ and NSAIDs were the most often reported drugs suspected to be responsible for drug hypersensitivities. Apart from the previous studies in which β ‐lactams and NSAIDs were the most commonly reported drugs that caused hypersensitivity reactions (11, 12, 14, 15), TMP–SMZ was the second most frequently reported drug suspected to be allergic in our population. In Turkey, β ‐lactams and TMP–SMZ are the two most often prescribed antibiotics for children, and although not the case for antibiotics, NSAIDs are easily obtained over the counter.…”

Section: Discussionmentioning

confidence: 63%

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Parental‐reported drug allergy in 6‐ to 9‐yr‐old urban schoolchildren

Orhan

Karakas

Çakır³

et al. 2008

Pediatric Allergy Immunology

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Epidemiologic studies about the prevalence of adverse drug reactions in children are scarce compared to reports in adults. To assess the prevalence of parental-reported drug allergy in 6- to 9-yr-old urban school children, we performed a cross-sectional study of 6- to 9-yr-old urban children from the eastern Black Sea region of Turkey during the year 2004, using a self-administered questionnaire by parents. Response rate was 81.6% (2855/3500). The prevalence of parental-reported drug allergy was 2.8% (81/2855). The most common parental-reported drugs were penicillins and other beta-lactams (59.3%), trimethoprim-sulfamethoxazole (11.1%), and acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (NSAIDs) (9.9%). The most commonly reported clinical manifestations were cutaneous (n = 76, 93.8%) followed by gastrointestinal (n = 17, 21%) symptoms. In 19 (23.5%) children, the reaction involved more than one organ system. Of these 19 children, 14 used beta-lactams. Systemic reactions were not reported with NSAIDs. Medications were taken by mouth in 88.9% of the reactions. Most of the reported allergic reactions occurred in the first day of treatment (61.7%). The reported time to reaction after the last intake of the drug was <2 h in 35 (43.2%) children and 2-24 h in 45 (55.6%). Oral reactions occurred later than reactions to parentally administered drugs. Parents of 58 children (71.6%) reported that they completely avoided the suspected culprit drug following the reaction. Relapse occurred after re-administration of the drug in 21 (25.9%) children. A diagnostic approach for drug allergy was not undertaken in any of the children. This study may provide some information about the prevalence of drug allergy, although it is based on parental perception and results are unlikely to conform well to true prevalence.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 63%

Parental‐reported drug allergy in 6‐ to 9‐yr‐old urban schoolchildren

Orhan

Karakas

Çakır³

et al. 2008

Pediatric Allergy Immunology

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“…6 The differences in the frequency of self-reported chloroquine allergy according to place of birth may reflect patterns of exposure to this drug. As in previous Western reports, allergy to antibiotics was the most frequent drug allergy, 1 particularly in university students, 5 and drug allergy (excluding chloroquine) was more frequent in women. [8][9][10] Students from health-related courses had a higher risk of drug allergy than other students, possibly reflecting easier access to medicines and a higher probability of sensitization.…”

supporting

confidence: 67%

Self-reported food and drug allergy in Maputo, Mozambique

et al. 2005

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There is wide regional variation in the prevalence of drug 1 and food 2,3 allergy. Although no data are available from developing countries, allergy frequency is expected to differ from that observed in more affluent regions, reflecting the genetic background, and the cultural and economic influences on exposure to allergens. This is the first report on prevalence estimates for food and drug allergy in an African country.Students (nZ447; one-third of all those registered; 44.7% male; age range: 18-56 years; median age: 25 years) and non-teaching staff (nZ62; 43.5% male; age range: 23-60 years; median age: 32 years) at a private university in Maputo volunteered to participate in a cross-sectional health survey with the main focus on the evaluation of risk factors for cardiovascular diseases, namely smoking, drinking, obesity and blood pressure. The questions 'Are you allergic to any food/drug?' and 'If yes, which food(s)/drug(s) are you allergic to?' were added to the questionnaire to ascertain allergy.Most participants (96.8%) were born in Mozambique, and were asked specifically about their place of birth. This was subsequently grouped into Maputo (Maputo city and Maputo province), South (provinces of Gaza and Inhambane), Centre (provinces of Manica, Sofala, Tete and Zambezia) and North (provinces of Nampula, Niassa and Cabo Delgado). Ethnicity was determined by self-identification, and participants were classified as either black or nonblack for data analysis.Odds ratios with 95% confidence intervals were computed to quantify the association between food/drug allergy and sociodemographic factors.The life prevalence of self-reported food allergy was 19.1%, and seafood (54.8%), meat (13.0%) and fruit/vegetables (13.0%) were the most frequently reported items. Food allergy decreased with age, from 22.6% in participants below 25 years of age to 12.0% in those above 35 years of age (P for trendZ0.03).

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“…Because only non-identified data were collected, we did not have the means to further verify individual reactions. Despite such limitations, it is a unique form of investigation among the drug hypersensitivity literature 2-4,6. Although many of these recalls might not reflect true hypersensitivity, these individuals will probably be labeled as allergic to drugs and be given second-line treatments, which are usually more expensive and less effective.…”

Section: Discussionmentioning

confidence: 99%

Drug hypersensitivity in students from São Paulo, Brazil

Ensina

Amigo

Koch

et al. 2010

Clinics

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BACKGROUND:Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce.METHODS:We performed a cross-sectional survey of 1015 university students, using a self-reported questionnaire.RESULTS:The prevalence of self-reported drug hypersensitivity was 12,11% (123/1015). The most frequently implicated drugs were non-steroidal anti-inflammatory drugs (45,9%) and beta-lactam and sulfonamide antibiotics (25,40%). The majority of the patients reported dermatological manifestations (99), followed by respiratory (40), digestive (23) and other (19). Forty-five patients had an immediate type reaction, and 76,72% (89) had the drug by oral route.CONCLUSION:The results showed that drug hypersensitivity is highly prevalent in university students, and that non-steroidal anti-inflammatory drug and antibiotics (beta-lactams and sulfonamide) are the most frequently concerned drugs.

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Drug allergy in university students from Porto, Portugal

Cited by 15 publications

References 3 publications

Parental‐reported drug allergy in 6‐ to 9‐yr‐old urban schoolchildren

Parental‐reported drug allergy in 6‐ to 9‐yr‐old urban schoolchildren

Self-reported food and drug allergy in Maputo, Mozambique

Drug hypersensitivity in students from São Paulo, Brazil

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