Drug Allergies May Be More Frequent in Systemic Lupus Erythematosus Than in Rheumatoid Arthritis

Abstract

Drug allergies are more frequent in SLE than in RA. Sulfa drugs are still the most frequent cause of drug allergies in SLE. Allergies because of drugs forbidden in the United States but easily available in specific ethnic groups are frequent in patients with SLE and RA. Their specific consumption must be intentionally assessed in cases of suspected drug allergies.

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

“…The low number of AIDS patients in our hospital might explain these findings. Previous studies have shown that the risk of allergic reactions in SLE patients is higher than in rheumatoid arthritis patients and healthy controls [1,14]. However, SLE was not identified as risk factor for cutaneous ADR in the present study.…”

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome

“…The drug hypersensitivity reactions in patients might be manifested by many cofactors, such as individual medical history, coadministered drugs, underlying diseases, viral infections, regulatory T-cell population/function, genetic polymorphisms of metabolic enzymes/immune-related genes, or autoimmune disorders. 39,40 Therefore the results presented in this study could not be extrapolated simply to the clinical situations of patients.…”

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome

“…For example, subjects with a prior medical history of viral infection (eg, HIV and human herpesvirus) or autoimmune disorders (eg, systemic lupus erythematosus) have been noted to be more susceptible to drug hypersensitivity. 33,34 Because OXC is the prodrug of CBZ and they share structural similarity, the cross-reactivity between CBZ and OXC to T cells has been examined in patients, and it has been reported that 33% of the patients who had a CBZ-induced rash also had OXC hypersensitivity. 35 T cells isolated from patients with CBZ hypersensitivity showed cross-reactivity to OXC in vitro.…”