Drug Adsorption in Human Skin: A Streaming Potential Study

Raiman, Johanna; Hänninen, Kaisa; Kontturi, Kyösti; Murtomäki, Lasse; Hirvonen, Jouni

doi:10.1002/jps.10516

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…Finally, both negative and positive compounds can interact with the sclera. Drug adsorption on connective tissues has been demonstrated with streaming potential measurements using molecules of different charge and MW . Also, neutral molecules could in principle interact with the sclera via nonionic interactions and specific binding sites: it has been found, for instance, that sclera contains binding sites for insulin and for insulin‐like growth factor‐1 .…”

Section: Resultsmentioning

confidence: 99%

Permeation of Proteins, Oligonucleotide and Dextrans Across Ocular Tissues: Experimental Studies and a Literature Update

Pescina

Govoni

Antopolsky

et al. 2015

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Permeation of Proteins, Oligonucleotide and Dextrans Across Ocular Tissues: Experimental Studies and a Literature Update

Pescina

Govoni

Antopolsky

et al. 2015

Journal of Pharmaceutical Sciences

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“…The extracellular stratum corneum lipid contains free fatty acids that can undergo dissociation, resulting in a negative surface charge caused by the presence of ionised carboxyl groups [51] . As the skin is a negatively‐charged membrane, this electrostatic interaction becomes a hindrance of ionised penetrants [52] . Thus, ionic compounds, particularly cations, have a lower ability to penetrate the skin compared with neutral compounds.…”

Section: Discussionmentioning

confidence: 99%

The application of feature selection to the development of Gaussian process models for percutaneous absorption

Lam

Sun

Davey

et al. 2010

Journal of Pharmacy and Pharmacology

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The use of a nonlinear GPR method produced models with significantly improved predictivity, compared with SLN or QSPR models. Feature selection methods were able to provide important mechanistic information. However, it was also shown that significant synergy existed between certain parameters, and as such it was possible to interchange certain descriptors (i.e. molecular weight and melting point) without incurring a loss of model quality. Such synergy suggested that a model constructed from discrete terms in an equation may not be the most appropriate way of representing mechanistic understandings of skin absorption.

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“…Similar trends have been observed in a previous study, although in this case LHRH was not found to exhibit any membrane activity at all. 5 According to the results obtained with nafarelin, both the lipophilic residue and the adjacent positive charge in the molecule were hypothesised to be crucial to the drug adsorption in the skin. 11 Despite carrying a more hydrophobic substituent group, nafarelin does not appear to be membrane active at a neutral monolayer.…”

confidence: 99%

“…† The peptides are electrically similar and their chemical structure differs by just one amino acid, glycine in LHRH is replaced by the more hydrophobic alanine in nafarelin, but studies have suggested that this is sufficient to induce a difference in their membrane activity. 5 The membrane activity of the peptides is studied as a function of peptide and membrane charge employing ac voltammetry at a biomimetic liquid-liquid interface. To this end a lipid monolayer was deposited at a water-nitrophenyl octyl ether (NPOE) gel interface using the Langmuir-Blodgett technique.…”

mentioning

confidence: 99%