Drug Addictions: An Historical and Ethological Overview

Belin, David; Belin, David

doi:10.5772/52165

Addictions - From Pathophysiology to Treatment 2012

DOI: 10.5772/52165

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Drug Addictions: An Historical and Ethological Overview

David Belin¹,

David Belin²

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2015

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“…Behaviourally, habitual cocaine seeking has been operationalized as instrumental responding in over-trained second-order schedules of reinforcement 35 36 (SOCR) procedures 5 15 37 38 whereby drug seeking during prolonged time periods is under the direct control of the conditioned reinforcing properties of cocaine CSs 39 .…”

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Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

Murray

Belin

Simon³

et al. 2015

Nat Commun

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In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits.

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mentioning

confidence: 99%

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

Murray

Belin

Simon³

et al. 2015

Nat Commun

Self Cite

View full text Add to dashboard Cite

show abstract

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Drug Addictions: An Historical and Ethological Overview

Cited by 1 publication

References 141 publications

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

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