Drug Abuse Warning Network, 2003: Interim National Estimates of Drug-Related Emergency Department Visits

Ball, Judy; Morin, Carol; Cover, Evarilla; Green, James; Sonnefeld, Joseph; Steele, Diane E.; Mallonee, Erin

doi:10.1037/e434932005-001

Cited by 2 publications

(2 citation statements)

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“…The Drug Abuse Warning Network estimates some 4,000 annual emergency department (ED) visits in which Ecstasy/MDMA is involved Ball et al 2004). ED surveys often report significant and malignant elevations in body temperature (Dams et al 2003;Gillman 1997;Greene et al 2003;Mallick and Bodenham 1997) but likely underrepresent the true prevalence of thermoregulatory distress.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys

Taffe

Lay

Huben

et al. 2006

Drug and Alcohol Dependence

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MDMA produces an acute hyperthermia in unrestrained rhesus monkeys, much as it does with rats, mice, pigs, rabbits and humans. Hyperthermia occurs despite no increase in locomotor activity thus the effect does not depend on motor activation. Each enantiomer appears to be equivalently active thus primates may differ from rodents in thermoregulatory sensitivity to the R(-) enantiomer. Significant differences in outcome between this and a prior study in monkeys indicate a need for additional study of the thermoregulatory impact of MDMA in nonhuman primates.

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Section: Introductionmentioning

confidence: 99%

Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys

Taffe

Lay

Huben

et al. 2006

Drug and Alcohol Dependence

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“…Many of the adverse clinical symptoms reported in Emergency Department (ED) visits in which 3,4-methylenedioxymethamphetamine (MDMA) or methamphetamine are involved (Ball et al, 2003;Ball et al, 2004) such as rhabdomyolysis, disseminated intravenous coagulation and acute renal failure (Henry et al, 1992;White, 2002) may result from hyperthermia (Buffum and Shulgin, 2001;Dams et al, 2003;Gillman, 1997;Green et al, 2003;Mallick and Bodenham, 1997;Prosser et al, 2006;Zhu et al, 2005). It is now well established that MDMA (considered the authentic compound in street "Ecstasy" tablets) can elevate temperature in humans (Freedman et al, 2005) and many other species (Brown and Kiyatkin, 2004;Carvalho et al, 2002;Dafters, 1994;Fantegrossi et al, 2003;Fiege et al, 2003;Pedersen and Blessing, 2001;Rosa-Neto et al, 2004;Saadat et al, 2004;Taffe et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of (±)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques

Crean¹,

Davis²,

Taffe³

2007

Pharmacology Biochemistry and Behavior

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Rationale-Emergency Department visits and fatalities in which (±)3,4-methylenedioxymethamphetamine (MDMA) or (+)methamphetamine (METH) are involved frequently feature unregulated hyperthermia. MDMA and METH significantly elevate body temperature in multiple laboratory species and, most importantly, can also produce unregulated and threatening hyperthermia in nonhuman primates. A majority of prior animal studies have administered drugs by injection whereas human consumption of "Ecstasy" is typically oral, an important difference in route of administration which may complicate the translation of animal data to the human condition.Objective-To determine if MDMA and METH produce hyperthermia in monkeys following oral administration as they do when administered intramuscularly.Methods-Adult male rhesus monkeys were challenged intramuscularly (i.m.) and per os (p.o.) with 1.78 or 5 mg/kg (±)MDMA and with 0.1 or 0.32 mg/kg (+)METH. Temperature and activity were monitored with a radiotelemetry system.Results-Oral administration of either MDMA or METH produced significant increases in body temperature. Locomotor activity was suppressed by MDMA and increased by METH following either route or administration.Conclusions-The data show that the oral route of administration is not likely to qualitatively reduce the temperature increase associated with MDMA or METH although oral administration did slow the rate of temperature increase. It is further established that MDMA reduces activity in monkeys even after relatively high doses and oral administration.

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Drug Abuse Warning Network, 2003: Interim National Estimates of Drug-Related Emergency Department Visits

Cited by 2 publications

References 0 publications

Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys

Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys

Oral administration of (±)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques

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