Drp1 expression levels correlate with clinical stage in extramammary Paget’s disease

Kitamura, Shinya; Yanagi, Teruki; Maeda, Takuya; Shimizu, Hiroshi

doi:10.1111/jdv.16422

Cited by 7 publications

(8 citation statements)

References 10 publications

(19 reference statements)

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“…A 'magic bullet' type of drug is unlikely to evolve soon, as the pathogenesis of AD is quite complex. 4 The first biologic is licensed for AD, 5 and additional innovative drugs will be approved soon. As these therapies will possess unprecedented efficacy, treatment goals in AD must be defined.…”

Section: European Task Force On Atopic Dermatitis (Etfad): Treatment mentioning

confidence: 99%

“…As observed by Fougerosse et al, 1 PASI-90 results were lower than that observed in phase III studies Voyage 1 (73.3%) and Voyage 2 (70%). 4,5 We compared the effectiveness of guselkumab at week 16 by assessing the number of patients who achieved PASI-100, PASI-90 and PASI-75 according to severity of the PASI at baseline and according to their belonging to the bio-naive or bio-experienced group. Effectiveness at week 16 is summarized in Table 1.…”

Section: Dear Editormentioning

confidence: 99%

“…F. Benhadou, 1,* X P.D. Ghislain, 2 F. Guiot, 3 F. Willaert, 1 V. Del Marmol, 1 J. Lambert, 4 R. Soenen, 4 H. Fierens, 5 M. de la Brassinne 6…”

Section: Conflicts Of Interestmentioning

confidence: 99%

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Real‐life effectiveness and short‐term (16‐week) tolerance of guselkumab for psoriasis: a Belgian retrospective multicentre study

Benhadou

Ghislain

Guiot³

et al. 2020

Acad Dermatol Venereol

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2c). Finally, we performed gene knockdown experiments. RANK knockdown induced a decrease in cell viability in the HAMON cells, not in the HUVECs (Fig. 2d-g). Mechanistically, knockdown of RANK suppressed the phosphorylation of Erk (Fig. 2f). In various cancers, positive associations between RANK-RANKL signalling and tumour development have been reported. 6 Recent clinical trials in lung cancer have shown that denosumab could reduce the risk of skeletal-related events and improve overall survival more than zoledronic acid. 7,8 Also, the RANK-RANKL signalling pathway is known to be involved in cancer cell migration and angiogenesis. 6 Jones et al. 9 demonstrated that the migration of RANK-expressing cancer cells was accelerated by RANKL, which is reported to be involved in the MAP kinase pathways. 6 Further, RANK-RANKL signalling pathways stimulate angiogenesis through an Src and phospholipase C-mechanism. 10 The results of the present and previous studies suggest that RANK-RANKL pathways highly contribute to angiogenesis and cell proliferation in CAS cells (Fig. 2h). In conclusion, we have reported a case of CAS with metastases in the sternum and liver which have remained stable through denosumab therapy. Also, we demonstrated that the RANK/ RANK pathway is activated in CAS. Our data suggest that the inhibition of RANK-RANKL signalling could be a potential treatment option for CAS.

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Section: European Task Force On Atopic Dermatitis (Etfad): Treatment mentioning

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

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Real‐life effectiveness and short‐term (16‐week) tolerance of guselkumab for psoriasis: a Belgian retrospective multicentre study

Benhadou

Ghislain

Guiot³

et al. 2020

Acad Dermatol Venereol

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“…18 Immunostaining was evaluated by the same observer; the total immunostaining score for CDK4 and cyclin D1 was calculated as the sum of proportion scores (0, absent; 1, 0%-25%; 2, 25%-50%; 3, 50%-75%; and 4, 75%-100%) and intensity scores (0, absent; 1, faint; 2, moderate; and 3, strong) in accordance with our previous study. 19 The proportion of immunoreactive cells was determined by counting 100 cells in three randomly chosen fields.…”

Section: Histopathologicalanalysesmentioning

confidence: 99%

Cyclin‐dependent kinase 4/6 inhibitors suppress tumor growth in extramammary Paget’s disease

et al. 2021

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Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy that occurs within the genital epithelium. 1 The incidence and mortality have been increasing over the last several decades. 2 A retrospective study reported that the 5-year overall survival rate for EMPD patients with distant metastasis was only 7%. 3 Some cytotoxic agents, such as docetaxel, cisplatin, and 5-fluorouracil, have been used to treat advanced EMPD; however, their efficacies are limited. 4,5 No standard therapies for advanced EMPD have been established; thus, efforts are needed to develop potential treatment options. The significance of PDX has been proven in the development of treatments for some cancers. 6 Patient-derived xenograft models can be established with the transplantation of cancerous cells or tissues from patients' tumors into immunodeficient mice. Patient-derived xenograft models can reproduce the conditions of human cancers better than conventional mouse models using cancer cell lines. In 2020, we established an EMPD-PDX model (EMPD-PDX-H1)

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“…To analyse the protein expressions of RANK/RANKL in CAS, we performed immunohistochemical analysis using samples of CAS and pyogenic granuloma (PG) ( n = 12, 8, respectively). Immunostaining score (IS) was evaluated according to the previous study 5 . The expression levels of RANK in CAS and PG were higher than those in normal endothelial cells ( P < 0.001) (Fig.…”

Section: Figurementioning

confidence: 99%

RANK‐RANKL signalling pathway contributes to disease progression in cutaneous angiosarcoma: a case report with an immunohistochemical review and in vitro experiments

Maeda

Kitamura

Yanagi

2020

Acad Dermatol Venereol

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In vitro studies have shown that the best algicidal effect in case of P. zopfii is obtained using products with carvacrol and thymol, and other polyphenols. The several reports have documented the antimicrobial effects of essential oils extracted from Melaleuca alternifolia (tea tree) and Citrus bergamota (bergamot). 2 The pharmacological treatment supported by regular podological procedures in patients with protothecosis prevents the onset and recurrence of annoying foot lesions. Due to sensitivity of the skin in podological surgeries, the procedure can be performed with a high security profile using specialized tools. It is also important not to use podological milling machine, because of the risk of infection spreading. Regular foot baths with tea tree oil once a day are also recommended. All authors were responsible for the concept and design of the study, collection and collation of data, analysis and interpretation of data, write an article, reviewing this article, final reviewing this article and graphics performance. The patient in this manuscript has given informed consent to publication of their case details.

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Drp1 expression levels correlate with clinical stage in extramammary Paget’s disease

Cited by 7 publications

References 10 publications

Real‐life effectiveness and short‐term (16‐week) tolerance of guselkumab for psoriasis: a Belgian retrospective multicentre study

Real‐life effectiveness and short‐term (16‐week) tolerance of guselkumab for psoriasis: a Belgian retrospective multicentre study

Cyclin‐dependent kinase 4/6 inhibitors suppress tumor growth in extramammary Paget’s disease

RANK‐RANKL signalling pathway contributes to disease progression in cutaneous angiosarcoma: a case report with an immunohistochemical review and in vitro experiments

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