In recent years, with the effect of the climate change, drought is accepted as one of the most important natural disasters. In the planning, development and management processes of water resources, studies on the analysis of past droughts and the decreasing of possible negative effects in the future, have become even more substantial. The best adaptation to drought risk can only be achieved by adopting holistic approaches. In this study, Dörtyol-Erzin Plain, which is located in the south of Turkey and covers the fertile agricultural lands of the Asi River Basin with a drainage area of approximately 7800 km2, was preferred as the case study for hydrological drought analysis. In the literature, it is stated that there is a slow drought progress for the Asi River Basin. It is highlighted that decreasing trend in groundwater and increasing trend in evaporation and temperature parameters are remarked. Since the agricultural irrigation of Dörtyol-Erzin Plain is dependent on groundwater and surface resources, hydrological drought analysis over the long period will be beneficial for the future studies. Accordingly, Streamflow Drought Index (SDI) method was used for the hydrological drought analysis by using 35 years of flow data between the years of 1986-2020. The open source “SPI_SL_6.exe” program via National Drought Mitigation Center (NDMC) was operated in the calculations. Drought results were analyzed at different time scales of 3, 6, 12, 24 and 48 months, afterwards relevant graphs and tables were created. Consequently, the longest dry period has been determined between 2008 and 2012 water years, while the wet period has been evaluated between 2003 and 2007 ones. Furthermore, it is concluded that SDI values decreased as the monthly time periods increased, while the maximum indice values were obtained with SDI-3 in all drought periods. When all graphs are examined detailed, it can be expressed long-term droughts for certain water years are notable.