Drospirenone Effects on the Plasminogen Activator System in Immortalized Human Endometrial Endothelial Cells

Sabouni, Reem; Archer, David F.; Jacot, Terry A.

doi:10.1007/s43032-020-00433-x

Cited by 1 publication

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“…MR has been demonstrated in endometrial glandular and stromal cells. We have identified MR in human immortalized endometrial endothelial cells and MR has been demonstrated in endothelial cells in other vascular beds [9,12,47]. We now have evidence for the first time that MR is present in the monkey endometrial glandular stromal and endothelial cells.…”

Section: Role Of Mineralocorticoid and Glucocorticoid Receptors In The Morphologic Changes Of The Endometriummentioning

confidence: 66%

“…Demonstration of MR within the endometrial vasculature holds potential implications for unscheduled uterine bleeding patterns, particularly in setting of hormonal contraceptive use. Given the anti-mineralocorticoid properties of certain progestins used for contraception and their association with decreased abnormal uterine bleeding patterns, MR antagonism particularly may in part explain these effects [12,13,47].…”

Section: Role Of Mineralocorticoid and Glucocorticoid Receptors In The Morphologic Changes Of The Endometriummentioning

confidence: 99%

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The Plasminogen Activator System, Glucocorticoid, and Mineralocorticoid Receptors in the Primate Endometrium During Artificial Menstrual Cycles

et al. 2021

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As a key mechanism in fibrinolysis and tissue remodeling, the plasminogen activator system has been suggested in the process of endometrial shedding and tissue remodeling. Previous studies have explored the role of estrogen, progesterone, and androgen receptors as well as elements of the renin-angiotensin-aldosterone system in shaping the morphology of the endometrium. This study investigates the distribution and concentrations of the mineralocorticoid receptor, glucocorticoid receptor, tissue plasminogen activator, urokinase plasminogen activator, and plasminogen activator inhibitor-1 within the endometrial stroma, glandular, and endothelial cells of the primate endometrium during artificial menstrual cycles. Our immunohistochemistry quantification shows mineralocorticoid and glucocorticoid receptors are ubiquitously distributed within the macaque endometrium with their patterns of expression following similar fluctuations to urokinase and tissue plasminogen activators particularly within the endometrial vasculature. These proteins are present in endometrial vasculature in high levels during the proliferative phase, decreasing levels during the secretory phase followed by rising levels in the menstrual phase. These similarities could suggest overlapping pathways and interactions between the plasminogen activator system and the steroid receptors within the endometrium. Given the anti-inflammatory properties of glucocorticoids and the role of plasminogen activators in endometrial breakdown, the glucocorticoid receptor may be contributing to stabilizing the endometrium by regulating plasminogen activators during the proliferative phase and menstruation. Furthermore, given the anti-mineralocorticoid properties of certain anti-androgenic progestins and their reduced unscheduled uterine bleeding patterns, the mineralocorticoid receptor may be involved in unscheduled endometrial bleeding.

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Section: Role Of Mineralocorticoid and Glucocorticoid Receptors In The Morphologic Changes Of The Endometriummentioning

confidence: 66%

Section: Role Of Mineralocorticoid and Glucocorticoid Receptors In The Morphologic Changes Of The Endometriummentioning

confidence: 99%

The Plasminogen Activator System, Glucocorticoid, and Mineralocorticoid Receptors in the Primate Endometrium During Artificial Menstrual Cycles

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Drospirenone Effects on the Plasminogen Activator System in Immortalized Human Endometrial Endothelial Cells

Cited by 1 publication

References 32 publications

The Plasminogen Activator System, Glucocorticoid, and Mineralocorticoid Receptors in the Primate Endometrium During Artificial Menstrual Cycles

The Plasminogen Activator System, Glucocorticoid, and Mineralocorticoid Receptors in the Primate Endometrium During Artificial Menstrual Cycles

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