“…Similar to mammalian TETs, Drosophila Tet (dTet) has been shown to regulate expression of genes involved in fly neurodevelopment and neuronal function, specifically important for behavior as well as learning and memory ( Yao et al, 2018 ). While dTet expression in fly brains has been mainly linked to neuronal expression during development ( Wang et al, 2018 ), dTet was more recently shown to be expressed in a specific glia population, the midline glial cells, where it plays an important role in axon guidance by controlling the expression level of the repulsive cue slit ( Ismail et al, 2019 ). A clear advantage of the Drosophila system is the lack of functional redundant TET homologs present in the mammalian system.…”