2001
DOI: 10.1016/s1534-5807(01)00075-2
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Drosophila Rolling pebbles

Abstract: The fusion of myoblasts leading to the formation of myotubes is an integral part of skeletal myogenesis in many organisms. In Drosophila, specialized founder myoblasts initiate fusion through expression of the receptor-like attractant Dumbfounded (Duf), which brings them into close contact with other myoblasts. Here, we identify Rols7, a gene expressed in founders, as an essential component for fusion during myotube formation. During fusion, Rols7 localizes in a Duf-dependent manner at membrane sites that cont… Show more

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Cited by 111 publications
(38 citation statements)
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“…In rols mutants syncytial longitudinal muscle development was disturbed, and we found mostly binucleated mini-muscles. The first fusion events of the longitudinal FCs might function without Rols7, analogous to the first phase of fusion in the somatic mesoderm, which is independent of Rols7 function [40,41,43]. In longitudinal visceral fusion, the adaptor protein Rols7 might bind to Duf/Kirre to allow efficient fusion via a positive feedback loop, as is the case in the somatic mesoderm [68].…”
Section: Discussionmentioning
confidence: 99%
“…In rols mutants syncytial longitudinal muscle development was disturbed, and we found mostly binucleated mini-muscles. The first fusion events of the longitudinal FCs might function without Rols7, analogous to the first phase of fusion in the somatic mesoderm, which is independent of Rols7 function [40,41,43]. In longitudinal visceral fusion, the adaptor protein Rols7 might bind to Duf/Kirre to allow efficient fusion via a positive feedback loop, as is the case in the somatic mesoderm [68].…”
Section: Discussionmentioning
confidence: 99%
“…Other fly stocks used include: mib1 EY9780 (Pitsouli and Delidakis, 2005), UAS-neur (Pavlopoulos et al, 2001), UAS-mib1-3 (Wang and Struhl, 2005), rP298-Gal4 (Menon and Chia, 2001), and ILK-GFP (Zervas et al, 2001). …”
Section: Methodsmentioning
confidence: 99%
“…The molecular composition of these vesicles requires future investigation. Another piece of evidence to support the involvement of vesicle trafficking in myoblast fusion is the finding that a founder cell-specific adaptor protein, Antisocial/Rolling pebbles (Ants/Rols) [55,57,58], functions to replenish the cell adhesion molecule Duf by translocating Duf in exocytic vesicles [59]. Moreover, genetics studies have implicated Singles bar (Sing), a MARVEL domain-containing four-pass transmembrane protein, in myoblast fusion [56] (Figure 2).…”
Section: Other Cellular Processes During Myoblast Fusionmentioning
confidence: 99%