Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF

Hyun, Sangwon; Lee, Youngseok; Hong, Sung-Tae; Bang, Sunhoe; Paik, Donggi; Kang, Jongkyun; Shin, Jinwhan; Lee, Jaejung; Jeon, Keun Hye; Hwang, Seungyoon; Bae, Eun-Kyung; Kim, Jaeseob

doi:10.1016/j.neuron.2005.08.025

Cited by 274 publications

(379 citation statements)

References 48 publications

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“…It is expressed in a broad subset of clock neurons, and a pdfr deletion is almost identical to the pdf 01 phenotype, including the advanced evening peak and fast pace in DD (8)(9)(10). Because PDF increases cAMP levels in at least some PDFR-expressing neurons (8,9,11,12), enhanced cAMP levels may slow the intrinsically fast pace of some PDFRcontaining clock neurons. cAMP may then affect clock speed only indirectly or by directly impacting the clock machinery.…”

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confidence: 99%

PDF and cAMP enhance PER stability in Drosophila clock neurons

Guo

Shen

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance This work describes an advance in the understanding of how the important circadian neuropeptide PDF contributes to the function of the molecular clock in Drosophila neurons. The famous per S allele of period significantly improves the rhythmicity of flies missing PDF. The per S gene product degrades rapidly, suggesting that PDF-mediated cAMP affects PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in tissue culture cells and in circadian neurons. PDF addition to fly brains in vitro has a similar effect. Our observations taken together indicate that PDF contributes to clock neuron function by activating PKA, stabilizing PER, and thereby slowing the pace of clock neurons that respond to PDF.

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confidence: 99%

PDF and cAMP enhance PER stability in Drosophila clock neurons

Guo

Shen

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…This latter function is strikingly similar to that of the 18-aa pigment-dispersing factor (PDF) in the Drosophila brain (13); the loss of PDF in flies and VIP in mice results in the inability to maintain strong, normally paced locomotor rhythms (14,15), and both peptides mediate communication between neurons of the circadian clock network (16)(17)(18)(19)(20). These similarities are molecular as well as functional; VPAC2 and PdfR, the PDF receptor in flies, are both type II secretin-like receptors (21)(22)(23). The peripheral roles of Drosophila PDF and its receptor have not been investigated.…”

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confidence: 89%

Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila

Talsma

Christov

Terriente‐Felix

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The role of the central neuropeptide pigment-dispersing factor (PDF) in circadian timekeeping in Drosophila is remarkably similar to that of vasoactive intestinal peptide (VIP) in mammals. Like VIP, PDF is expressed outside the circadian network by neurons innervating the gut, but the function and mode of action of this PDF have not been characterized. Here we investigate the visceral roles of PDF by adapting cellular and physiological methods to the study of visceral responses to PDF signaling in wild-type and mutant genetic backgrounds. We find that intestinal PDF acts at a distance on the renal system, where it regulates ureter contractions. We show that PdfR, PDF's established receptor, is expressed by the muscles of the excretory system, and present evidence that PdfR-induced cAMP increases underlie the myotropic effects of PDF. These findings extend the similarities between PDF and VIP beyond their shared central role as circadian regulators, and uncover an unexpected endocrine mode of myotropic action for an intestinal neuropeptide on the renal system. intestine | tubule | enteric | nervous system

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“…These PDF neurons send axonal projections to the dorsal protocerebrum and the optic lobes [147][148][149][150], and in Pdf mutants, the circadian phenotypes of locomotor activity [150] and adult eclosion are disrupted [115]. The G-protein coupled PDF receptor is also expressed in the PI, suggesting that PDF could signal along the neuroendocrine axis [151,152].…”

Section: Circadian Signalling and Diapause: What Is The Link?mentioning

confidence: 99%

The hormonal and circadian basis for insect photoperiodic timing

2011

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Edited by Martha Merrow and Michael BrunnerKeywords: Insects Photoperiodism Diapause Endocrine axis Circadian clock Clock genes a b s t r a c t Daylength perception in temperate zones is a critical feature of insect life histories, and leads to developmental changes for resisting unfavourable seasons. The role of the neuroendocrine axis in the photoperiodic response of insects is discussed in relation to the key organs and molecules that are involved. We also discuss the controversial issue of the possible involvement of the circadian clock in photoperiodicity. Drosophila melanogaster has a shallow photoperiodic response that leads to reproductive arrest in adults, yet the unrivalled molecular genetic toolkit available for this model insect should allow the systematic molecular and neurobiological dissection of this complex phenotype.

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Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF

Cited by 274 publications

References 48 publications

PDF and cAMP enhance PER stability in Drosophila clock neurons

PDF and cAMP enhance PER stability in Drosophila clock neurons

Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila

The hormonal and circadian basis for insect photoperiodic timing

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