“…The RNA-binding and endoribonuclease activities of EndoU family members were first shown in Xenopus by in vitro assays (Laneve et al, 2003;Renzi et al, 2006) and have since been confirmed in diverse organisms ranging from bacteria to humans (Ivanov et al, 2004;Laneve et al, 2008Laneve et al, , 2017Michalska et al, 2018;Poe et al, 2014;Schwarz and Blower, 2014;Ujisawa et al, 2018). EndoU family members appear to be involved in many aspects of biology, including small nucleolar RNA biogenesis (Renzi et al, 2006), endoplasmic reticulum (ER) network formation (Schwarz and Blower, 2014), immune response (Poe et al, 2014), neurodegeneration (Laneve et al, 2017), and viral replication (Ivanov et al, 2004), and as antibacterial toxins (Michalska et al, 2018;Zhang et al, 2011). Human EndoU, also known as PP11 (placental protein 11), has been suggested to be a tumor marker because it is expressed in various tumors despite having no detectable expression in tissues other than the placenta (Laneve et al, 2008).…”