Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development

Kanuka, Hirotaka; Kuranaga, Erina; Takemoto, Kiwamu; Hiratou, Tetsuo; Okano, Hideyuki; Miura, Masayuki

doi:10.1038/sj.emboj.7600822

Cited by 102 publications

(153 citation statements)

References 60 publications

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“…This process involves Droncmediated cleavage of Shaggy (Sgg46), which negatively regulates Wingless signaling required for SOP formation. 80 In turn, Dronc activity is positively regulated by Drosophila IκK, DmIKK, which degrades the caspase inhibitor protein DIAP1, to control SOP development. 81 In mammals, caspase function in terminal differentiation has also been described in various cell types (Table 1), including keratinocytes, megakaryocytes, erythrocytes and lens cells.…”

Section: Caspases In Cell-fate Determination and Differentiationmentioning

confidence: 99%

Old, new and emerging functions of caspases

et al. 2014

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Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell death, mediating both receptor-mediated apoptosis and in its absence, necroptosis. Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population. Caspase-3 has important roles in tissue differentiation, regeneration and neural development in ways that are distinct and do not involve any apoptotic activity. Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 and -14. However, increased caspase-2 and -8 expression in certain types of tumor has also been linked to promoting tumorigenesis. Increased levels of caspase-3 in tumor cells causes apoptosis and secretion of paracrine factors that promotes compensatory proliferation in surrounding normal tissues, tumor cell repopulation and presents a barrier for effective therapeutic strategies. Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability, metabolism, autophagy and aging. The present review focuses on some of these less studied and emerging functions of mammalian caspases.

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Section: Caspases In Cell-fate Determination and Differentiationmentioning

confidence: 99%

Old, new and emerging functions of caspases

et al. 2014

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“…Apoptotic gene mutant flies exhibit one or several extra macrochaetes on their notum. One proposed mechanism is that the lack of caspase activation in sensory organ precursor (SOP) cells leads to Wingless signaling activation and the formation of an extra sensory neuron [39].…”

Section: Role Of Caspases In Non-apoptotic Cellular Functionsmentioning

confidence: 99%

Cell death: what can we learn from flies? Editorial for the special review issue on Drosophila apoptosis

Mollereau

2009

Apoptosis

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“…The following fly strains were used in this work: UAS-SCAT3 (25), UAS-DRONC DN/TM3 (26), N393/Binsinscy (16), and sca-Gal4/CyO (27). To generate the E93 and ␤FTZ-F1 mutants expressing SCAT3, E93 1 /TM6b, Df(3R)93F x2 /TM6b, ␤FTZ-F1 17 /TM6b, and ␤FTZ-F1 19 /TM6b (27) were used.…”

Section: Methodsmentioning

confidence: 99%

“…The salivary glands were placed immediately on coverslips. FRET images in fixed salivary glands were collected by confocal microscopy as described in our previous report (25).…”

Section: Detailed Spatiotemporal Pattern Analysis In Dissected Salivarymentioning

confidence: 99%

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Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo

Takemoto

Kuranaga

Tonoki

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Programmed cell death, or apoptosis, is an essential event in animal development. Spatiotemporal analysis of caspase activation in vivo could provide new insights into programmed cell death occurring during development. Here, using the FRET-based caspase-3 indicator, SCAT3, we report the results of live-imaging analysis of caspase activation in developing Drosophila in vivo. In Drosophila, the salivary gland is sculpted by caspase-mediated programmed cell death initiated by the steroid hormone 20-hydroxyecdysone (ecdysone). Using a SCAT3 probe, we observed that caspase activation in the salivary glands begins in the anterior cells and is then propagated to the posterior cells in vivo. In vitro salivary gland culture experiments indicated that local exposure of ecdysone to the anterior salivary gland reproduces the caspase activation gradient as observed in vivo. In ␤FTZ-F1 mutants, caspase activation was delayed and occurred in a random pattern in vivo. In contrast to the in vivo response, the salivary glands from ␤FTZ-F1 mutants showed a normal in vitro response to ecdysone, suggesting that ␤FTZ-F1 may be involved in ecdysteroid biosynthesis and secretion of ecdysone from the ring gland for local initiation of programmed cell death. These results imply a role of ␤FTZ-F1 in coordinating the initiation of salivary gland apoptosis in development.apoptosis ͉ imaging ͉ metamorphosis ͉ FRET ͉ ecdysone

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Drosophila caspase transduces Shaggy/GSK-3β kinase activity in neural precursor development

Cited by 102 publications

References 60 publications

Old, new and emerging functions of caspases

Old, new and emerging functions of caspases

Cell death: what can we learn from flies? Editorial for the special review issue on Drosophila apoptosis

Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo

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