Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
Lei Chang,
Yang Xie,
Brett Taylor
et al.
Abstract:Current methods for analyzing chromatin architecture are not readily scalable to heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial microfluidic device for high-throughput, single-cell chromatin conformation profiling in droplets. Using Droplet Hi-C, we mapped the chromatin architecture of the mouse cortex and analyzed gene regulatory programs in major cortical cell types. In addition, we used this technique to detect copy number variations, structural variations and extrachromosoma… Show more
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