Droplet behavior and its effects on flow characteristics in T-junction microchannels

Pang, Yan; Lu, Yao; Wang, Xiang; Liu, Zhaomiao

doi:10.1063/5.0052636

Cited by 13 publications

(3 citation statements)

References 27 publications

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“…Both the flow distribution of the continuous phase and the droplet size tend to be uniform. The variation of resistance of multiphase flow plays a key role in flow distribution . The droplets generated in M-2 are shown in Figure b, and the uniformity of droplets is excellent.…”

Section: Resultsmentioning

confidence: 97%

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Formation of Droplets of Shear-Thinning Non-Newtonian Fluids in Asymmetrical Parallelized Microchannels

et al. 2023

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Fluids containing polymers are frequently utilized in the chemical industry and exhibit shear-thinning characteristics. The flow distribution of non-Newtonian fluids in parallelized microchannels is a key issue to be solved during numbering-up. Numbering-up means increasing the number of parallelized microchannels. In this study, a high-speed camera is used to explore the distribution of fluid flow as well as the uniformity and stability of droplets in conceptual asymmetrical parallelized microchannels. Cyclohexane and carboxymethylcellulose sodium (CMC) aqueous solutions are used as the continuous phase and dispersed phase, respectively. The effects of fluctuation of pressure difference around the T-junction, the hydrodynamic resistance in microchannels, and the shear-thinning property of fluids on flow distribution and droplet formation are revealed. The uniformity and stability of droplets in microdevices with various cavity settings are compared, and an optimal configuration is proposed. Finally, prediction models for the flow distribution of shear-thinning fluids in asymmetrical parallelized microchannels are established.

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Section: Resultsmentioning

confidence: 97%

“…The variation of resistance of multiphase flow plays a key role in flow distribution. 36 The droplets generated in M-2 are shown in Figure 11b, and the uniformity of droplets is excellent. The E(L) < 5%, as exhibited in Figure 13b.…”

Section: Optimization Of Cavity Settings 351 Distribution Of Fluid Fl...mentioning

confidence: 93%

Formation of Droplets of Shear-Thinning Non-Newtonian Fluids in Asymmetrical Parallelized Microchannels

et al. 2023

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“…The Micro-droplet methodology is a high-throughput technology using very low amount of reagents, user-friendly and with least cross contaminations between reagents [ 18 ]. Pang et al [ 19 ] reported a droplet-based MFS and its effects on flow using a continuous stream of two or more immiscible fluids producing droplets at the T-junction. The T-junction is one of the most commonly used geometries.…”

Section: Microfluidicsmentioning

confidence: 99%

Microfluidics-Based Nanobiosensors for Healthcare Monitoring

2023

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Efficient healthcare management demands prompt decision-making based on fast diagnostics tools, astute data analysis, and informatics analysis. The rapid detection of analytes at the point of care is ensured using microfluidics in synergy with nanotechnology and biotechnology. The nanobiosensors use nanotechnology for testing, rapid disease diagnosis, monitoring, and management. In essence, nanobiosensors detect biomolecules through bioreceptors by modulating the physicochemical signals generating an optical and electrical signal as an outcome of the binding of a biomolecule with the help of a transducer. The nanobiosensors are sensitive and selective and play a significant role in the early identification of diseases. This article reviews the detection method used with the microfluidics platform for nanobiosensors and illustrates the benefits of combining microfluidics and nanobiosensing techniques by various examples. The fundamental aspects, and their application are discussed to illustrate the advancement in the development of microfluidics-based nanobiosensors and the current trends of these nano-sized sensors for point-of-care diagnosis of various diseases and their function in healthcare monitoring.

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Applications of microfluidics in biosensing

Sekhwama,

Mpofu,

Sivarasu

et al. 2024

Discov Appl Sci

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Microfluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They have such a wide range of uses and can make complex tasks quite efficient. One area of research or work that has benefited greatly from the use of microfluidics is biosensing, where microfluidic chips are integrated into biosensor setups. There are growing numbers of applications of microfluidics in this area as researchers look for efficient ways to tackle disease diagnostics and drug discovery, which are critical in this era of recurring pandemics. In this work, the authors review the integration of microfluidic chips with biosensors, as well as microfluidic applications in biosensing, food security, molecular biology, cell diagnostics, and disease diagnostics, and look at some of the most recent research work in these areas. The work covers a wide range of applications including cellular diagnostics, life science research, agro-food processing, immunological diagnostics, molecular diagnostics, and veterinarian diagnostics. Microfluidics is a field which combines fundamental laws of physics and chemistry to solve miniaturization problems involving fluids at the nanoscale and microscale, and as such, the authors also examine some fundamental mathematical concepts in microfluidics and their applications to biosensing. Microfluidics has relatively new technologies with great potential in terms of applications.

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Droplet behavior and its effects on flow characteristics in T-junction microchannels

Cited by 13 publications

References 27 publications

Formation of Droplets of Shear-Thinning Non-Newtonian Fluids in Asymmetrical Parallelized Microchannels

Formation of Droplets of Shear-Thinning Non-Newtonian Fluids in Asymmetrical Parallelized Microchannels

Microfluidics-Based Nanobiosensors for Healthcare Monitoring

Applications of microfluidics in biosensing

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